Predicting neurodevelopmental outcomes in preterm infants: A comprehensive evaluation of neonatal and maternal risk factors

Faramarzi, Raheleh; Darabi, Azadeh; Maamouri, Gholamali; Rezvani, Reyhane

doi:10.1016/j.earlhumdev.2023.105834

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…LBW categories were associated with longer preterm infant hospital stays and more maternal admissions, emphasizing the need for comprehensive support strategies for LBW infants and their mothers. These findings align with those of previous studies showing that longer hospital stays are linked to LBW [ 26 , 27 ]. Mehretie et al’s cross-sectional study further linked gestational age, complications, and initial management with the duration of hospital stay of VLBW preterm neonates [ 28 ].…”

Section: Discussionsupporting

confidence: 93%

The Prevalence and Risk Analysis of Cerebral Palsy and Other Neuro-Psychological Comorbidities in Children with Low Birth Weight in Taiwan: A Nationwide Population-Based Cohort Study

Fan,

Chang,

Lee

et al. 2024

JCM

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Background: This study evaluated early childhood comorbidities of cerebral palsy (CP) in low birth weight (LBW) children and assessed the impact of maternal bio-psychosocial factors on CP risk in preterm infants of varying birth weights (BWs). Methods: Data from 15,181 preterm infants (2009–2013) and 151,810 controls were analyzed using Taiwan’s National Health Insurance Research Database. CP prevalence and LBW-associated comorbidities were examined, and odds ratios (ORs) were calculated. Results: This study confirmed increasing prematurity and LBW rates in Taiwan, with LBW infants showing higher CP prevalence. Significant maternal risk factors included age extremes (<20 and >40 years). LBW infants exhibited higher risks for respiratory, circulatory, nervous system, and psycho-developmental comorbidities compared with controls, with the lowest BW having even higher ORs. Maternal factors such as family income, the number of hospital admissions, and length of hospital stay were remarkably correlated with BW and subsequent complications. Each additional gestational week crucially reduced the risk of complications in premature infants. Conclusions: LBW infants are at a higher risk for CP and various comorbidities, with maternal bio-psychosocial factors playing a critical role. Addressing these factors in prenatal care and interventions is essential to improve outcomes for premature infants.

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Section: Discussionsupporting

confidence: 93%

The Prevalence and Risk Analysis of Cerebral Palsy and Other Neuro-Psychological Comorbidities in Children with Low Birth Weight in Taiwan: A Nationwide Population-Based Cohort Study

Fan,

Chang,

Lee

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…LBW categories were associated with longer preterm infant hospital stays and more maternal admissions, emphasizing the need for comprehensive support strategies for LBW infants and their mothers. These findings align with those of previous studies showing that longer hospital stays are linked to LBW [24,25]. Mehretie et al's cross-sectional study further linked gestational age, complications, and initial management with duration of hospital stay of VLBW preterm neonates [26].…”

Section: Discussionsupporting

confidence: 89%

The Prevalence and Risk Analysis of Cerebral Palsy in Children with Low Birth weight in Taiwan: A Nationwide Population-Based Cohort Study

Fan,

Chang,

Lee

et al. 2024

Preprint

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This study aimed to evaluate the early-childhood comorbidities of cerebral palsy (CP) in children with low birth weight (LBW) and assess the impact of maternal bio-psychosocial factors on the risk of CP in preterm infants across varying birth weights. Data for 15,181 prematurely born infants from 2009 to 2013 and 151,810 matched controls from Taiwan's National Health Insurance Research Database were analyzed. Period prevalence of CP, and comorbidities of LBW were verified, and odds ratios (ORs) were calculated. Results confirmed that increasing prematurity and low birth weight (LBW) rates in Taiwan. LBW was associated with higher CP prevalence. Maternal age extremes (&lt;20 and &gt;40 years) were significant risk factors of CP in LBW infants. LBW infants showed higher risks of respiratory, circulatory, and nervous system and psycho-developmental comorbidities compared to controls. Infants with the lowest birth weights had even higher ORs for these comorbidities. However, gastrointestinal and nutritional comorbidities were less prevalent in premature infants. Maternal factors such as family income, number of hospital admissions, and length of hospital stay were significantly correlated with birth weight and subsequent complications. Each additional gestational week significantly reduced the risk of complications in premature infants. Additionally, maternal bio-psychosocial factors were associated with birth weight and related outcomes in premature infants, emphasizing the importance of addressing these factors in prenatal care and interventions.

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“…This study focused solely on newborn risk factors. Maternal risk factors, such as diabetes in pregnancy, preeclampsia, hypothyroidism, the premature rupture of membranes, abnormal ultrasound findings during pregnancy, maternal drug usage, antepartum hemorrhage, oligohydramnios, chronic medical illness, multiple pregnancies, assisted reproductive techniques, and maternal age, may have varying effects on different areas of MLPT population development [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between General Movements and Risk Factors in Moderate-Late Preterm Infants: A Prospective Cohort Study

Merino-Andrés,

Pérez-Nombela,

Hidalgo-Robles

et al. 2023

JCM

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Introduction: Moderate-late preterm infants constitute the largest segment of preterm births globally. While previously considered to have a low neurological risk, recent research has uncovered an elevated incidence of neurodevelopmental conditions in this group. This study aimed to assess the relationship between the general movement assessment and birth-related risk factor-based tools in moderate-late preterm infants. Methods: A prospective cohort study of 65 moderate-late preterm infants in a neonatal intensive care unit involved the evaluation of general movements, the Nursery Neurobiologic Risk Score, and the Perinatal Risk Inventory. Associations were analyzed using Fisher’s exact test, Spearman’s correlation was used for ordinal variables, and backward stepwise logistic regression was used to identify predictor variables for the assessments. Results: The findings indicated a high prevalence of normal (41%) and poor (52%) repertoire patterns during the writhing period. While no significant associations were found between the three assessments, a slight approximation emerged between dysmorphic traits and patterns (p = 0.053). Furthermore, an extended period of ventilation correlated with a higher likelihood of developing a cramped synchronized pattern and there was a correlation between both risk factor-based tools (p < 0.001). Conclusions: This research enhances our understanding of the early impact on general movement assessments in moderate-late preterm infants. While no clear relationship emerged between general movement assessment and risk factor-based tools, there was a subtle connection noted with dysmorphic traits. A longer ventilation duration was linked to a higher risk of developing cramped synchronized patterns.

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Predicting neurodevelopmental outcomes in preterm infants: A comprehensive evaluation of neonatal and maternal risk factors

Cited by 5 publications

References 20 publications

The Prevalence and Risk Analysis of Cerebral Palsy and Other Neuro-Psychological Comorbidities in Children with Low Birth Weight in Taiwan: A Nationwide Population-Based Cohort Study

The Prevalence and Risk Analysis of Cerebral Palsy and Other Neuro-Psychological Comorbidities in Children with Low Birth Weight in Taiwan: A Nationwide Population-Based Cohort Study

The Prevalence and Risk Analysis of Cerebral Palsy in Children with Low Birth weight in Taiwan: A Nationwide Population-Based Cohort Study

The Relationship between General Movements and Risk Factors in Moderate-Late Preterm Infants: A Prospective Cohort Study

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