Predicting nanocarrier permeation across the human intestinein vitro: Model matters
Nathalie Jung,
Jonas Schreiner,
Florentin Baur
et al.
Abstract:For clinical translation of oral nanocarriers, simulation of the complex intestinal microenvironment is crucial to evaluate interactions and transport across the intestinal mucosa for predicting the drug’s bioavailability. However, permeation studies are often conducted using simplistic cell culture models, overlooking key physiological factors such as tissue composition, morphology, and additional diffusion barriers as constituted by mucus. This oversight may potentially lead to an incomplete evaluation of th… Show more
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