Predicting lymph node metastasis in patients with papillary thyroid carcinoma by vascular index on power Doppler ultrasound

Lee, Ji Hye; Shin, Hyun Joo; Yoon, Jung Hyun; Kim, Min Jung; Moon, Hee Jung; Lee, Hye Sun; Kwon, Hyeong Ju

doi:10.1002/hed.24592

Cited by 13 publications

(9 citation statements)

References 49 publications

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“…[ 17 ] achieved the opposite result. Furthermore, for Doppler, the resistive index (RI) and vascular index (VI) were not significantly correlated to LN metastasis [ 12 , 27 ]. In addition, Acu et al .…”

Section: Discussionmentioning

confidence: 99%

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Ardakani¹,

Rasekhi²,

Mohammadi³

et al. 2018

Pol J Radiol

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PurposePapillary thyroid carcinoma (PTC) is the most common thyroid cancer, and cervical lymph nodes (LNs) are the most common extrathyroid metastatic involvement. Early detection and reliable diagnosis of LNs can lead to improved cure rates and management costs. This study explored the potential of texture analysis for texture-based classification of tumour-free and metastatic cervical LNs of PTC in ultrasound imaging.Material and methodsA total of 274 LNs (137 tumour-free and 137 metastatic) were explored using the texture analysis (TA) method. Up to 300 features were extracted for texture analysis in three normalisations (default, 3sigma, and 1-99%). Linear discriminant analysis was employed to transform raw data to lower-dimensional spaces and increase discriminative power. The features were classified by the first nearest neighbour classifier.ResultsNormalisation reflected improvement on the performance of the classifier; hence, the features under 3sigma normalisation schemes through FFPA (fusion Fisher plus the probability of classification error [POE] + average correlation coefficients [ACC]) features indicated high performance in classifying tumour-free and metastatic LNs with a sensitivity of 99.27%, specificity of 98.54%, accuracy of 98.90%, positive predictive value of 98.55%, and negative predictive value of 99.26%. The area under the receiver operating characteristic curve was 0.996.ConclusionsTA was determined to be a reliable method with the potential for characterisation. This method can be applied by physicians to differentiate between tumour-free and metastatic LNs in patients with PTC in conventional ultrasound imaging.

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Section: Discussionmentioning

confidence: 99%

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Ardakani¹,

Rasekhi²,

Mohammadi³

et al. 2018

Pol J Radiol

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“…It regulates regulatory T cells (regulatory T cells). cells, Treg) and immune suppression [6,7]. At the same time, FOXP3 can exert an immunosuppressive function by regulating the content of anti-in ammatory factors such as IL-10 and TGFβ, and the expression of thousands of proteins in the body is also regulated by it [8].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Pan-Cancer Analysis of 33 Human Cancers Reveals the Immunotherapy Value of FOXP3

chen

Zhou

Gong

et al. 2022

Preprint

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Background: Previous studies reported that FOXP3 is involved in the regulation of tumor microenvironment and the regulation of tumor local immunity. However, its mechanism has not been fully studied. This study aims to explore the potential relationship between FOXP3 and cancer immunotherapy in 33 human cancers.Method: The gene expression data and clinical characteristics of 33 cancers were retrieved from the Cancer Genome Atlas database. The immunotherapy cohort includes GSE157893, GSE67501, and IMvigor210, which come from a comprehensive gene expression database and are included in previously published studies. Analyze clinical parameters, including patient age, gender, and tumor stage to assess the prognostic value of FOXP3. At the same time, we conducted survival analysis and correlation analysis of tumor microenvironment. The correlation between FOXP3 and immunosuppressive agents and stimulants, as well as major histocompatibility complexes was also analyzed. Potential pathways related to FOXP3 signaling in cancer have also been explored. In addition, the correlation between FOXP3 and two immunotherapy biomarkers (tumor mutation burden and microsatellite instability) was studied. Finally, the immunotherapy response relationship between FOXP3 and the immunotherapy cohort was explored.Results: Among 33 cancer types, FOXP3 expression is different in different clinical groups (gender, age, and tumor stage) in certain cancers, and it also shows potential prognostic value in predicting patient survival. FOXP3 is correlated with immune cell infiltration, immunomodulators and immunotherapy markers. In addition, low FOXP3 expression is significantly associated with certain pathways. However, no significant correlation was observed between FOXP3 and immunotherapy response.Conclusion: This study explored the immunotherapy value of FOXP3 in 33 human cancers, and provided evidence and insights for the application of FOXP3 in tumor immunotherapy. However, considering the bioinformatics methods used in this study, the findings of the study are only preliminary, and more relevant experimental verifications are needed.

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“…Ultrasound is the most important modality for evaluating thyroid cancer, according to the ATA Statement on Preoperative Imaging for Thyroid Cancer Surgery (13). There are studies on the use of ultrasound images to predict CLNM in patients with PTC (14)(15)(16)(17)(18), but the false negative rate reaches 80% (19). Studies to develop a model for prediction of CLNM in patients with cN0 PTC are especially limited.…”

Section: Introductionmentioning

confidence: 99%

Nomogram to Assess the Risk of Central Cervical Lymph Node Metastasis in Patients With Clinical N0 Papillary Thyroid Carcinoma

et al. 2021

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Predicting lymph node metastasis in patients with papillary thyroid carcinoma by vascular index on power Doppler ultrasound

Abstract: Although the VI showed significant correlation with MVD, it was not significantly correlated to lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 39: 334-340, 2017.

Cited by 13 publications

References 49 publications

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Comprehensive Pan-Cancer Analysis of 33 Human Cancers Reveals the Immunotherapy Value of FOXP3

Nomogram to Assess the Risk of Central Cervical Lymph Node Metastasis in Patients With Clinical N0 Papillary Thyroid Carcinoma

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