Predicting lung exposure of intramuscular niclosamide as an antiviral agent: Power‐law based pharmacokinetic modeling
Taeheon Kim,
Woojin Jung,
Sangeun Cho
et al.
Abstract:Niclosamide, a potent anthelmintic agent, has emerged as a candidate against COVID‐19 in recent studies. Its formulation has been investigated extensively to address challenges related to systemic exposure. In this study, niclosamide was formulated as a long‐acting intramuscular injection to achieve systemic exposure in the lungs for combating the virus. To establish the dose–exposure relationship, a hamster model was selected, given its utility in previous COVID‐19 infection studies. Pharmacokinetic (PK) anal… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.