Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin

Serum neutrophil gelatinase-associated lipocalin at 3 hours after return of spontaneous circulation in patients with cardiac arrest and therapeutic hypothermia: early predictor of acute kidney injury

“…In a 2019 study by Lee et al [33], the plasma NGAL measured 4 h after ROSC among adult OHCA patients who were treated with TTM was associated with both the neurologic outcome at the time of discharge (adjusted OR 1.004; 95% CI 1.001-1.007) as well as the 28-day mortality rate (adjusted OR 1.003; 95% CI 1.001-1.004). In 2018, Park et al [34] reported that the NGAL level was measured immediately and 24, 46, and 72 h after ROSC and was analysed to predict the long-term outcome and survival in 76 OHCA patients who underwent TTM; the results showed that the NGAL value measured after 72 h was the optimal predictive indicator for the outcome and survival (AUROC = 0.72; p = 0.02). In a 2017 study, Kaneko et al [35] analysed the neurologic outcome at discharge based on NGAL measurements at 1 and 2 days after ROSC; the NGAL level after 2 days showed a comparable predictive value as the 2-day neuron-specific enolase, which has widespread application in the prediction of the neurologic outcome.…”

“…In this study, the results of multivariate regression analysis of ROSC-NGAL and 3 h-NGAL measurements did not identify them as significant risk factors for poor neurologic outcome (ROSC-NGAL: OR 1.017; 95% CI 0.998-1.036; p = 0.084, 3 h-NGAL: OR 0.997; 95% CI 0.992-1.001; p = 0.113). The neuroprognostic value of NGAL measured within 24 h is remains controversial [34]; therefore, additional studies are necessary to determine the optimal timepoints for NGAL measurement after ROSC.…”

Serum Neutrophil Gelatinase-associated Lipocalin at 3 Hours after Return of Spontaneous Circulation in Patients with Cardiac Arrest and Therapeutic Hypothermia: Early Predictor of Acute Kidney Injury

“…In a 2019 study by Lee et al [34], the plasma NGAL measured 4 hours after ROSC among adult OHCA patients who were treated with TTM was associated with both the neurologic outcome at the time of discharge (adjusted OR 1.004; 95% CI 1.001-1.007) as well as the 28-day mortality rate (adjusted OR 1.003; 95% CI 1.001-1.004). In 2018, Park et al [35] reported that the NGAL level was measured immediately and 24, 46, and 72 hours after ROSC and was analysed to predict the long-term outcome and survival in 76 OHCA patients who underwent TTM; the results showed that the NGAL value measured after 72 hours was the optimal predictive indicator for the outcome and survival (AUROC = 0.72; p =0.02). In a 2017 study, Kaneko et al [36] analysed the neurologic outcome at discharge based on NGAL measurements at 1 and 2 days after ROSC; the NGAL level after 2 days showed a comparable predictive value as the 2-day neuron-speci c enolase, which has widespread application in the prediction of the neurologic outcome.…”

Serum Neutrophil Gelatinase-associated Lipocalin at 3 Hours after Return of Spontaneous Circulation in Patients with Cardiac Arrest and Therapeutic Hypothermia: Early Predictor of Acute Kidney Injury

“…In a 2019 study by Lee et al [34], the plasma NGAL measured 4 hours after ROSC among adult OHCA patients who were treated with TTM was associated with both the neurologic outcome at the time of discharge (adjusted OR 1.004; 95% CI 1.001-1.007) as well as the 28-day mortality rate (adjusted OR 1.003; 95% CI 1.001-1.004). In 2018, Park et al [35] reported that the NGAL level was measured immediately and 24, 46, and 72 hours after ROSC and was analysed to predict the long-term outcome and survival in 76 OHCA patients who underwent TTM; the results showed that the NGAL value measured after 72 hours was the optimal predictive indicator for the outcome and survival (AUROC = 0.72; p =0.02). In a 2017 study, Kaneko et al [36] analysed the neurologic outcome at discharge based on NGAL measurements at 1 and 2 days after ROSC; the NGAL level after 2 days showed a comparable predictive value as the 2-day neuron-speci c enolase, which has widespread application in the prediction of the neurologic outcome.…”

“…The peak creatinine level was signi cantly different according to the AKI stages: 1. 35 The intergroup differences in neurologic outcomes at discharge (GNO group vs PNO group) showed that the PNO group (CPC 3-5) included 54 patients (60.7%). There were no signi cant between-group differences in the sex distribution, mean age, and presence of underlying diseases in the GNO and PNO groups.…”