While the fraternity continues to ponder on the mechanisms by which coronavirus
disease (COVID-19) positivity affects the outcome of cardiac surgical subset, we
put forth a 3H (Hypoxia-Hemolysis-Hyperinflammation) trilogy aimed at
elucidating the liaison between cardiopulmonary bypass (commonly employed for
cardiac surgical conduct) and COVID-19 infection. A sound comprehension of the
same can doubtlessly assist the perioperative team in staging a well-directed
pathophysiology-driven management approach.