Predicting High-Value Care Outcomes After Surgery for Non–Skull Base Meningiomas

Jimenez, Adrian E.; Chakravarti, Sachiv; Liu, Sophie; Wu, Esther; Wei, Oren; Shah, P.; Nair, Sumil K.; Gendreau, Julian; Porras, Jose L.; Azad, Tej D.; Jackson, Christopher M.; Gallia, Gary L.; Bettegowda, Chetan; Weingart, Jon; Brem, Henry; Mukherjee, Debraj

doi:10.1016/j.wneu.2021.12.010

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Meningioma studies similarly found significant relationships between frailty and mortality, extended hospital LOS, hospital readmission rates, and postoperative complications [ 32 – 42 ]. However, studies also noted a relationship between frailty and unplanned reoperation, non-home discharge dispositions, KPS deterioration [ 32 , 35 , 36 ]. A relationship between frailty and a variety of postoperative complications, extended hospital LOS and readmission rates, non-home discharges, and mortality was reported in patients with vestibular schwannoma [ 44 – 48 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology

Qureshi,

Tabor,

Pickens

et al. 2023

J Neurooncol

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Purpose Frailty has gained prominence in neurosurgical oncology, with more studies exploring its relationship to postoperative outcomes in brain tumor patients. As this body of literature continues to grow, concisely reviewing recent developments in the field is necessary. Here we provide a systematic review of frailty in brain tumor patients subdivided by tumor type, incorporating both modern frailty indices and traditional Karnofsky Performance Status (KPS) metrics. Methods Systematic literature review was performed using PRISMA guidelines. PubMed and Google Scholar were queried for articles related to frailty, KPS, and brain tumor outcomes. Only articles describing novel associations between frailty or KPS and primary intracranial tumors were included. Results After exclusion criteria, systematic review yielded 52 publications. Amongst malignant lesions, 16 studies focused on glioblastoma. Amongst benign tumors, 13 focused on meningiomas, and 6 focused on vestibular schwannomas. Seventeen studies grouped all brain tumor patients together. Seven studies incorporated both frailty indices and KPS into their analyses. Studies correlated frailty with various postoperative outcomes, including complications and mortality. Conclusion Our review identified several patterns of overall postsurgical outcomes reporting for patients with brain tumors and frailty. To date, reviews of frailty in patients with brain tumors have been largely limited to certain frailty indices, analyzing all patients together regardless of lesion etiology. Although this technique is beneficial in providing a general overview of frailty’s use for brain tumor patients, given each tumor pathology has its own unique etiology, this combined approach potentially neglects key nuances governing frailty’s use and prognostic value.

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