Abstract:Mutations in theKCNH2gene cause long or short QT syndromes (LQTS or SQTS) predisposing to life-threatening arrhythmias.KCNH2encodes for the voltage-gated K+channel hERG involved in the late repolarization phase of the cardiac action potential (AP). For the last decades, sequencingKCNH2has provided a plethora of variants associated or not with clear pathological cardiac phenotypes. Identifying pathogenic or likely pathogenic variants from the benign ones would provide useful information to clarify the genetic b… Show more
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