“…There's been several reports on the risk of sICH after MT in LIC, none of which showed an increase in the risk of sICH after MT except in the HERMES collaboration 3 where, for patients with ASPECTS 0-4, sICH was more frequent in the MT group, although not significantly (adjusted cOR, 3.94; 95% CI, 0.94 to 16.49; P interaction=0.025), and not reproduced when restricting the sample to patients with DWI volume ≥70 mL were no significant difference of sICH between EVT (1/23, 4.3%) and best medical treatment (2/37, 5.4%) was found. 3,15 Of critical note, the most important predictor of sICH and parenchymal hemorrhage is core volume, independent of treatment modality, 3,7,19,20,23 likely explaining that successful reperfusion was associated with lower sICH in many "real life" recent studies. 7,19,20 Whether the benefits of not revascularizing a patient to prevent sICH, outweigh those of revascularization to prevent infarction extension is unknown, but very unlikely, especially in patients with important mismatch, at highest risk for infarct progression and progression to malignant infarction.…”