Abstract:Background: High flow nasal cannula (HFNC) is commonly used as non-invasive respiratory support in critically ill children. There are limited data to inform consensus on optimal device parameters, determinants of successful patient response, and indications for escalation of support. Clinical scores, such as the respiratory rate-oxygenation (ROX) index, have been described as a means to predict HFNC non-response, but are limited to evaluating for escalations to invasive mechanical ventilation (MV). In the pres… Show more
“…They found that an ROX index above 66.7 at 24 hours after HFNC had 86% sensitivity, 79% specificity, 23.1% PPV, and 98.8% NPV. A previous retrospective study by Krachman et al [ 16 ] used machine learning algorithms of ROX index to predict flow rate escalation. In the present study, we used the normal RR for age to adjust the ROX index.…”
Section: Discussionmentioning
confidence: 99%
“…A previous retrospective study by Krachman et al. (17) used machine learning algorithms of ROX index to predict flow rate escalation. In the present study, we used the normal RR for age to adjust the ROX index.…”
The study was approved by the Institutional Review Board, and written informed consent was obtained from the parents/guardians of the patients before inclusion.
“…They found that an ROX index above 66.7 at 24 hours after HFNC had 86% sensitivity, 79% specificity, 23.1% PPV, and 98.8% NPV. A previous retrospective study by Krachman et al [ 16 ] used machine learning algorithms of ROX index to predict flow rate escalation. In the present study, we used the normal RR for age to adjust the ROX index.…”
Section: Discussionmentioning
confidence: 99%
“…A previous retrospective study by Krachman et al. (17) used machine learning algorithms of ROX index to predict flow rate escalation. In the present study, we used the normal RR for age to adjust the ROX index.…”
The study was approved by the Institutional Review Board, and written informed consent was obtained from the parents/guardians of the patients before inclusion.
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