Predicting Fetal Lung Maturity by Visual Assessment of Amniotic Fluid Turbidity

Adair, Charles; Sánchez-Ramos, Luis; McDyer, D L; Gaudier, Francisco L.; Valle, Gerardo O. Del; Delke, Isaac

doi:10.1097/00007611-199510000-00006

Cited by 7 publications

(7 citation statements)

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“…In a recent study in the literature using this test Adair et al (22) We should not forget that assessment of fetal lung maturation is one of the most important steps while deciding in birth of the fetus. The objective should be protection of the fetus from risks such as sequelae of RDS, necrotizing enterocolitis, intraventricular hemorrhage, patent ductus arteriozus and neonatal sepsis as much as possible.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of fetal lung maturity by turbidity testing and tap test

Kars¹,

Yasemin²,

Karsidag³

et al. 2011

J Turk Soc Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

Evaluation of fetal lung maturity by turbidity testing and tap test

Kars¹,

Yasemin²,

Karsidag³

et al. 2011

J Turk Soc Obstet Gynecol

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“…During the third trimester, vernix gradually accumulates on the fetal skin surface and subsequently detaches, contributing to the turbidity of amniotic fl uid [11] . The mechanism of this detachment is likely multifactorial, but in vitro assays have demonstrated dose-dependent, pulmonary surfactant-mediated detachment of vernix [9] .…”

Section: Discussionmentioning

confidence: 99%

“…Biol Neonate 2005;87:8-14 11 crimination of adjacent skin regions. Cleansing effi cacy was quantifi ed as percent of skin with residual soil using a statistically nested design.…”

Section: Vernix As a Skin Cleansermentioning

confidence: 99%

A Novel Role for Vernix caseosa as a Skin Cleanser

et al. 2005

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Objectives: Skin cleansing is a complex process involving endogenous and exogenous mechanisms. This study examines the role of vernix caseosa in the process of skin cleansing in the perinatal period. Methods: Vernix was evaluated as an exogenously applied skin cleanser using digitized image analysis which quantified residual carbon particles following a standardized cleansing assay. In addition, the detachment of vernix from human cadaveric skin and Gore-Tex^® supports was investigated following timed exposures to a variety of commonly used commercial surfactants. Detachment was quantified spectrophotometrically as increased turbidity at 650 nm. Results: Image analysis showed that exogenous application of vernix exhibited a cleansing capability comparable or superior to standard skin cleansers. Dose-dependent increases in solution turbidity (vernix detachment) were seen following exposure of vernix-covered Gore-Tex vehicles to sodium laureth sulfate, sodium lauryl sulfate, and cocamidopropyl betaine solutions. Similar results were seen with cadaveric skin. Conclusions: These results demonstrate a role for vernix caseosa as a skin cleanser. Previous views of vernix as a soil or skin contaminant at birth need to be reevaluated.

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“…Prenatally, vernix performs a similar function coupling the developing skin surface of the late gestation foetus with the amniotic fluid. During the third trimester of pregnancy, there is a progressive increase in the turbidity of the amniotic fluid surrounding the foetus [34]. This turbidity has been assayed as an index of foetal lung maturity by various methods ranging from spectrophotometry to visual examination.…”

Section: Physical Propertiesmentioning

confidence: 99%

The biology of vernix caseosa

Hoath¹,

Pickens²,

Visscher³

2006

Intern J of Cosmetic Sci

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The biology and physical properties of the uniquely human skin cream 'vernix caseosa' are discussed. This material coats the foetal skin surface during the last trimester of gestation and provides multiple beneficial functions for the foetus and newborn infant. Vernix has a complex structure similar to stratum corneum but lacks lipid lamellae and is more plastic due to the absence of desmosomal constraints. In utero, vernix is made in part by foetal sebaceous glands, interacts with pulmonary surfactant, detaches into the amniotic fluid, and is swallowed by the foetus. At the time of birth, vernix has a remarkably constant water content approximating 80%. Postnatally, vernix is simultaneously a cleanser, a moisturizer, an antiinfective, and an anti-oxidant. Vernix facilitates acid mantle development and supports normal bacterial colonization. Its hydrated cellular structure and unusual lipid composition provide a 'best' solution for the needs of the foetus and newborn, not least of which is the attraction of caregivers. Vernix is an important natural biomaterial of potential interest to cosmetic scientists, and other disciplines involved in product development and therapies targeting the complex interface between the stratum corneum and a changing terrestrial environment. Ré suméLa biologie et les propriétés physiques de la crème de peau exclusivement humaine 'Vernix caseosa « sont discutées. Ce matériau couvre la surface de la peau foetale pendant le dernier trimestre de gestation et remplit des fonctions avantageuses multiples pour le foetus et le nouveau-né. Le Vernix a une structure complexe semblable au stratum corneum, mais manque de lamelles lipidiques et est plus plastique en raison de l'absence de contraintes desmosomales. In utero, le Vernix est constitué en partie par des glandes sébacées foetales, il interagit avec le surfactant pulmonaire, il se détache dans le liquide amniotique et est avalé par le foetus. Au moment de la naissance, le Vernix a une teneur remarquablement constante en eau de l'ordre de 80%. Après la naissance, le Vernix devient simultanément un produit de lavage, un produit hydratant, un anti-infectieux et un anti-oxydant. Le Vernix facilite le développement du manteau acide et soutient la colonisation bactérienne normale. Sa structure cellulaire hydratée et sa composition en lipide inhabituelle en font 'une des meilleures » solutions pour les besoins du foetus et du nouveau-né, à laquelle le personnel soignant n'attache pas la moindre importance. Le Vernix est un biomatériau naturel important potentiellement inté-ressant pour les scientifiques cosméticiens et pour les autres disciplines impliquées dans le développe-ment de produits et de thérapies visant l'interface complexe entre le stratum corneum et un environnement terrestre changeant.

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Predicting Fetal Lung Maturity by Visual Assessment of Amniotic Fluid Turbidity

Cited by 7 publications

References 0 publications

Evaluation of fetal lung maturity by turbidity testing and tap test

Evaluation of fetal lung maturity by turbidity testing and tap test

A Novel Role for Vernix caseosa as a Skin Cleanser

The biology of vernix caseosa

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