Predicting effects of methylphenidate and sulpiride on brain and cognition: A pharmaco-fMRI, PET study. Design and descriptives.

Määttä, Jessica I; Bosch, Ruben van den; Papadopetraki, Danae; Hofmans, Lieke; Lambregts, Britt; Westbrook, Andrew; Verkes, Robbert‐Jan; Cools, Roshan

doi:10.31219/osf.io/d3h8e

Cited by 6 publications

(6 citation statements)

References 72 publications

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“…Data were collected as part of a large PET, pharmaco-fMRI study on the effects of methylphenidate and sulpiride on brain and cognition, employing a within-subject, placebo- controlled, double-blind cross-over design. For a detailed description of the testing sessions and tasks and measures collected, see Määttä et al (2021).…”

Section: Methodsmentioning

confidence: 99%

“…This study is part of a larger project (Määttä et al, 2021), for which 100 healthy volunteers were recruited, 50 women and 50 men (age at inclusion: ranged 18 to 43, mean (SD) = 23.0 (5.0) years). All participants provided written informed consent and were paid 309 euro on completion of the overarching study.…”

Section: Methodsmentioning

confidence: 99%

“…This study is part of a larger project (Määttä et al, 2021), for which 100 healthy volunteers were recruited, 50 women and 50 men (age at inclusion: ranged 18 to 43, mean (SD) = 23.0…”

Section: Participantsmentioning

confidence: 99%

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Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

Bosch

Hezemans

Määttä

et al. 2022

Preprint

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Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity and spontaneous eye-blink rate (sEBR), as measured with readily available and easily administered, off-the-shelf tests. Such findings have raised the suggestion that individual variation in dopamine synthesis capacity, estimated with expensive and invasive brain positron emission tomography (PET) scans, can be approximated with simple, more pragmatic tests. However, direct evidence for the relationship between these simple trait measures and striatal dopamine synthesis capacity has been limited and inconclusive. We measured striatal dopamine synthesis capacity using [18F]-FDOPA PET in a large sample of healthy volunteers (N=94) and assessed the correlation with simple, short tests of working memory capacity, trait impulsivity, and sEBR. We additionally explored the relationship with an index of subjective reward sensitivity. None of these trait measures correlated significantly with striatal dopamine synthesis capacity, nor did they have out-of-sample predictive power. Bayes Factor analyses indicated the evidence was in favor of absence of correlations for all but subjective reward sensitivity. These results warrant caution for using these off-the-shelf trait measures as proxies of striatal dopamine synthesis capacity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

Bosch

Hezemans

Määttä

et al. 2022

Preprint

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“…2021 [67]. The study was approved by the regional research ethics committee (Commisssie Mensgebonden Onderzoek, region Arnhem-Nijmegen; 2016/2646; ABR: NL57538.091.16).…”

Section: Methodsmentioning

confidence: 99%

Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper

Westbrook,

van den Bosch,

Hofmans

et al. 2024

Preprint

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Associations can be learned incrementally, via reinforcement learning (RL), or stored instantly in working memory (WM). While WM is fast, it is also capacity-limited and effortful. Striatal dopamine may promote RL plasticity, and WM, by facilitating updating and effort exertion. Yet, prior studies have failed to distinguish between dopamine's effects on RL versus WM. N = 100 participants completed a paradigm isolating these systems in a double-blind study measuring dopamine synthesis with [18F]-FDOPA imaging and manipulating dopamine with methylphenidate and sulpiride. Learning is enhanced among high synthesis capacity individuals and by methylphenidate, but impaired by sulpiride. Methylphenidate also blunts effort cost learning. Computational modeling reveals that individuals with high dopamine synthesis rely more on WM, while methylphenidate boosts their RL rates. The D2 antagonist sulpiride reduces accuracy due to diminished WM involvement and faster WM decay. We conclude that dopamine enhances both slow RL, and fast WM, by promoting plasticity and reducing effort sensitivity. These results also highlight the need to control for dopamine's effects on WM when testing its effects on RL.

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“…The data reported here were acquired in the context of a larger pharmacological PET/fMRI study, components of which have been and will be reported separately (Hofmans et al, 2020(Hofmans et al, , 2022Määttä et al, 2021;van den Bosch, Hezemans, et al, 2022;van den Bosch, Lambregts, et al, 2022;Westbrook et al, 2020; an overview of the complete study at https://osf.io/d3h8e). For this study, participants paid five visits.…”

Section: General Proceduresmentioning

confidence: 99%

Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.

Chen¹,

Geurts²,

Määttä³

et al. 2023

Behavioral Neuroscience

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Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([ 18 F]-DOPA PET) in healthy participants (N = 100) to assess whether dopamine synthesis capacity (K i ), specifically in the ventral striatum, accounts for individual variation in Pavlovian-to-instrumental transfer (PIT). Surprisingly, this was not the case. Rather, the relationship of ventral striatal K i with PIT depended on working memory (WM) capacity. Ventral striatal dopamine boosted the effects of Pavlovian cues on instrumental responding to a greater degree in participants with higher WM capacity. Caution is warranted to interpret this post hoc four-way interaction given the modest sample size. Nonetheless, these results chime with prior findings demonstrating that dopaminergic drugs boost Pavlovian biases to a greater degree in participants with greater WM capacity and highlight the importance of interactions between striatal dopamine and WM capacity.

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Predicting effects of methylphenidate and sulpiride on brain and cognition: A pharmaco-fMRI, PET study. Design and descriptives.

Cited by 6 publications

References 72 publications

Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper

Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.

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