“…Due to their high value and detailed structural characterization, Bcl-xL, MDM2, and IL-2 have all been used for successful validation of virtual screening methods (Betzi et al 2009;Sperandio et al 2010;Casey et al 2009;Fuller et al 2009;Helms 2007, 2009;Enyedy et al 2001;Bowman et al 2007;Mukherjee et al 2010). Bcl-xL and MDM2, in particular, have attracted special attention for in silico screening against molecules in existing chemical libraries.…”