Predicting different adhesive regimens of circulating particles at blood capillary walls

Coclite, Alessandro; Mollica, Hilaria; Ranaldo, Sergio; Pascazio, G.; Tullio, Marco D. de; Decuzzi, Paolo

doi:10.1007/s10404-017-2003-7

Cited by 21 publications

(20 citation statements)

References 45 publications

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“…We note that the model described in Equation ( 11) is similar to models used in other investigations involving cell adhesion. For instance, a similar spring-like adhesion force to model receptor-ligand binding between particles and walls in the context of blood flow has been used for many years [48][49][50][51]. Our model differs in four main ways from such work.…”

Section: Model For Apical Hooksmentioning

confidence: 99%

“…Our model has no surface of a cell, but rather a single point at the head of the flagellum that can bind. Second, bond formation and dissolution is different: for our model, the apical hook force is applied only when flagellar heads are within a fixed distance of another flagellum, whereas there is a probabilistic approach for forming and breaking bonds in [48][49][50][51]. Third, we are modeling a much larger structure than receptors and ligands.…”

Section: Model For Apical Hooksmentioning

confidence: 99%

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Flagellar Cooperativity and Collective Motion in Sperm

Simons

Rosenberger

2021

Fluids

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Sperm have thin structures known as flagella whose motion must be regulated in order to reach the egg for fertilization. Large numbers of sperm are typically needed in this process and some species have sperm that exhibit collective or aggregate motion when swimming in groups. The purpose of this study is to model planar motion of flagella in groups to explore how collective motion may arise in three-dimensional fluid environments. We use the method of regularized Stokeslets and a three-dimensional preferred curvature model to simulate groups of undulating flagella, where flagellar waveforms are modulated via hydrodynamic coupling with other flagella and surfaces. We find that collective motion of free-swimming flagella is an unstable phenomenon in long-term simulations unless there is an external mechanism to keep flagella near each other. However, there is evidence that collective swimming can result in significant gains in velocity and efficiency. With the addition of an ability for sperm to attach and swim together as a group, velocities and efficiencies can be increased even further, which may indicate why some species have evolved mechanisms that enable collective swimming and cooperative behavior in sperm.

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Section: Model For Apical Hooksmentioning

confidence: 99%

Section: Model For Apical Hooksmentioning

confidence: 99%

Flagellar Cooperativity and Collective Motion in Sperm

Simons

Rosenberger

2021

Fluids

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“…Since then, this Adhesive-Dynamics model (AD) has been extended to study many biologically relevant problems, such as the hydrodynamic recruitment of rolling leukocytes [40], platelet-surface and platlet-platlet interactions [49,50]. Note also that the current model does not account for the stochastic formation and rupture of ligand receptor bonds, which can be readily included following previous works by the authors and others [30,39,40].…”

Section: Wall-particle Interactionsmentioning

confidence: 99%

“…In recent years the Lattice Boltzmann method (LBM) has been widely used as a fluid solver in IBM schemes [26][27][28]. In 2D problems, LBM-IBM approach with elastic spring networks has been extensively documented in simulation of transport of RBCs, cells and particles in microcapillaries [29][30][31]. In 3D simulations, community codes such as LAMMPAS (large-scale atomic/molecular massively parallel simulator) and ESPResSo (Extensible Simulation Package for RESearch on SOft matter) have been recentely proposed [32,33].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Vascular Fate of Deformable Circulating Tumor Cells Via a Hierarchical Computational Model

2019

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Introduction -Distant spreading of primary lesions is modulated by the vascular dynamics of circulating tumor cells (CTCs) and their ability to establish metastatic niches. While the mechanisms regulating CTC homing in specific tissues are yet to be elucidated, it is well documented that CTCs possess different size, biological properties and deformability.Methods -A computational model is presented to predict the vascular transport and adhesion of CTCs in whole blood. A Lattice-Boltzmann method, which is employed to solve the Navier-Stokes equation for the plasma flow, is coupled with an Immersed Boundary Method. Results -The vascular dynamics of a CTC is assessed in large and small microcapillaries. The CTC shear modulus k ctc is varied returning CTCs that are stiffer, softer and equally deformable as compared to RBCs. In large microcapillaries, soft CTCs behave similarly to RBCs and move away from the vessel walls; whereas rigid CTCs are pushed laterally by the fast moving RBCs and interact with the vessel walls. Three adhesion behaviors are observed -firm adhesion, rolling and crawling over the vessel walls -depending on the CTC stiffness. On the contrary, in small microcapillaries, rigid CTCs are pushed downstream by a compact train of RBCs and cannot establish any firm interaction with the vessel walls; whereas soft CTCs are squeezed between the vessel wall and the RBC train and rapidly establish firm adhesion. Concluisons -These findings document the relevance of cell deformability in CTC vascular adhesion and provide insights on the mechanisms regulating metastasis formation in different vascular districts. arXiv:1907.09284v1 [cond-mat.soft]

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“…In this work, a dynamic-Immersed-Boundary (IB) method is combined with a Multi-Relaxationtime Lattice Boltzmann (MRT-LB) scheme for describing the evolution of capsules transported in incompressible flows [19]. This method was extensively studied and validated by Coclite and collaborators [20][21][22][23][24][25]. Here, the authors propose an extension of such scheme to non-Newtonian fluids.…”

Section: Introductionmentioning

confidence: 99%

Capsules Rheology in Carreau–Yasuda Fluids

Coclite

Tommasi

2020

Nanomaterials

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In this paper, a Multi Relaxation Time Lattice Boltzmann scheme is used to describe the evolution of a non-Newtonian fluid. Such method is coupled with an Immersed-Boundary technique for the transport of arbitrarily shaped objects navigating the flow. The no-slip boundary conditions on immersed bodies are imposed through a convenient forcing term accounting for the hydrodynamic force generated by the presence of immersed geometries added to momentum equation. Moreover, such forcing term accounts also for the force induced by the shear-dependent viscosity model characterizing the non-Newtonian behavior of the considered fluid. Firstly, the present model is validated against well-known benchmarks, namely the parabolic velocity profile obtained for the flow within two infinite laminae for five values of the viscosity model exponent, n = 0.25, 0.50, 0.75, 1.0, and 1.5. Then, the flow within a squared lid-driven cavity for Re = 1000 and 5000 (being Re the Reynolds number) is computed as a function of n for a shear-thinning (n < 1) fluid. Indeed, the local decrements in the viscosity field achieved in high-shear zones implies the increment in the local Reynolds number, thus moving the position of near-walls minima towards lateral walls. Moreover, the revolution under shear of neutrally buoyant plain elliptical capsules with different Aspect Ratio (AR = 2 and 3) is analyzed for shear-thinning (n < 1), Newtonian (n = 1), and shear-thickening (n > 1) surrounding fluids. Interestingly, the power law by Huang et al. describing the revolution period of such capsules as a function of the Reynolds number and the existence of a critical value, Rec, after which the tumbling is inhibited in confirmed also for non-Newtonian fluids. Analogously, the equilibrium lateral position yeq of such neutrally buoyant capsules when transported in a plane-Couette flow is studied detailing the variation of yeq as a function of the Reynolds number as well as of the exponent n.

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Predicting different adhesive regimens of circulating particles at blood capillary walls

Abstract: dynamics of particles with arbitrary geometries and surface properties and represents a fundamental tool in the rational design of particles for the specific delivery of therapeutic and imaging agents.

Cited by 21 publications

References 45 publications

Flagellar Cooperativity and Collective Motion in Sperm

Flagellar Cooperativity and Collective Motion in Sperm

Unraveling the Vascular Fate of Deformable Circulating Tumor Cells Via a Hierarchical Computational Model

Capsules Rheology in Carreau–Yasuda Fluids

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