Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure

Abstract

In ambulant outpatients with chronic HF, low serum sodium and SDNN and high serum creatinine identify patients at increased risk of death due to progressive HF.

Principais características clínicas de pacientes que sobrevivem 24 meses ou mais após uma hospitalização devido a descompensação cardíaca

“…The population in this study seems more severely ill than those usually described in epidemiological studies, or even in large assays, because no study reported mortality greater than 50% [1][2][3][4][5][7][8][9][10]13,14 .…”

“…Patients with heart failure who require hospitalization for compensation usually have the advanced form of the disease, and evolve with higher mortality rates than that of those who remained compensated on an outpatient care basis only [1][2][3][4][5][7][8][9][10] .…”

“…In population-based studies, 10% to 20% of patients with heart failure die in the first year of evolution, and this number may reach 50% in a 5-year follow-up [1][2][3][4][5] . When analyzing the survival of patients hospitalized with heart failure, the numbers are not encouraging, with a 30 to 40% mortality in the first year of follow-up [7][8][9][10] .…”

“…Blood pressure levels < 100 mm Hg are associated with greater mortality 3,7,19 . Cardiac function is another important prognostic determinant 5,10,15,16 . Our data show that patients with greater cardiac impairment, smaller cardiac dilation, and greater ejection fraction survive longer.…”

“…Our data show that patients with greater cardiac impairment, smaller cardiac dilation, and greater ejection fraction survive longer. This shows that for the population of patients with advanced heart failure, cardiac remodeling, which is more and more identified as a mechanism of disease progression, plays an unquestionable role in the natural history of the disease 5,10,15,16,20 . The patients with left ventricular diastolic diameter > 7.8 cm had a risk of death almost two times greater than that of patients with smaller dilation (HR 1.95) ( fig.…”