Predicting Creatinine Clearance for Rational Dosage Adjustments in the Elderly.

Predictive performance of serum digoxin concentration in patients with congestive heart failure by a hyperbolic model based on creatinine clearance

“…This was because slight estimation errors in the Ccr values could probably be offset by interindividual variability in non‐renal clearance. It seems that the use of the Ccr value calculated from the CG‐equation should be encouraged for predicting serum digoxin level, given the high correlation coefficient ( r =0·81) observed and widespread familiarity with the CG‐equation (8, 24). The coefficient of determination ( r 2 =0·66) accounted well for the proportion of the amount of digoxin administered which was recovered unchanged in the urine.…”