Predicting COVID-19 progression in hospitalized patients in Belgium from a multi-state model

Mertens, Elly; Serrien, Ben; Vandromme, Mathil; Peñalvo, José L.

doi:10.3389/fmed.2022.1027674

Cited by 2 publications

(3 citation statements)

References 53 publications

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“…In patients diagnosed with SARS-CoV-2 infection, higher CRP levels have been associated with severe pulmonary pathology and with worse overall outcomes [12][13][14][15][16][18][19][20][21][22]. Moreover, elevated CRP has been used as a predictor of COVID-19 severity and mortality [5][6][7][8][9][10][11]. However, patients with SARS-CoV-2 present for medical attention at differing points in their illness [47].…”

Section: Discussionmentioning

confidence: 99%

“…Peak CRP levels occur about 48 h after an acute infection with a half-life of 19 h; levels may rise >1000-fold following acute infection or tissue injury [4]. CRP levels have been used for predicting COVID-19 disease severity [5][6][7][8][9][10][11]. Patients who were ultimately intubated, diagnosed with severe disease, or had worsened computer tomography (CT) severity scores often had elevated CRP levels [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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CRP Monitoring in Early Hospitalization: Implications for Predicting Outcomes in Patients with COVID-19

Avihai,

Sundel,

Lee

et al. 2023

Pathogens

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Elevated C-reactive protein (CRP) levels have been associated with poorer COVID-19 outcomes. While baseline CRP levels are higher in women, obese individuals, and older adults, the relationship between CRP, sex, body mass index (BMI), age, and COVID-19 outcomes remains unknown. To investigate, we performed a retrospective analysis on 824 adult patients with COVID-19 admitted during the first pandemic wave, of whom 183 (22.2%) died. The maximum CRP value over the first five hospitalization days better predicted hospitalization outcome than the CRP level at admission, as a maximum CRP > 10 mg/dL independently quadrupled the risk of death (p < 0.001). Males (p < 0.001) and patients with a higher BMI (p = 0.001) had higher maximum CRP values, yet CRP levels did not impact their hospitalization outcome. While CRP levels did not statistically mediate any relation between sex, age, or BMI with clinical outcomes, age impacted the association between BMI and the risk of death. For patients 60 or over, a BMI < 25 kg/m2 increased the risk of death (p = 0.017), whereas the reverse was true for patients <60 (p = 0.030). Further impact of age on the association between BMI, CRP, and the risk of death could not be assessed due to a lack of statistical power but should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CRP Monitoring in Early Hospitalization: Implications for Predicting Outcomes in Patients with COVID-19

Avihai,

Sundel,

Lee

et al. 2023

Pathogens

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“…In Brazil, the COVID-19 burden was substantial, and related casualties in the same period reached 690,000 2 . The disease pathophysiology and risk factors associated with higher in-hospital mortality have been extensively studied to improve its clinical management and to identify patients with poor prognosis at early stages 3 .…”

Section: Introductionmentioning

confidence: 99%

Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease

Lomba,

Silva,

Rosário

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a sixmonth follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06,) and longer hospital stay (HR 1.01, 95%CI 1.00 -1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.

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Predicting COVID-19 progression in hospitalized patients in Belgium from a multi-state model

Cited by 2 publications

References 53 publications

CRP Monitoring in Early Hospitalization: Implications for Predicting Outcomes in Patients with COVID-19

CRP Monitoring in Early Hospitalization: Implications for Predicting Outcomes in Patients with COVID-19

Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease

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