Predicting concordance of biochemical lung maturity in the preterm twin gestation

Mackenzie, M.

doi:10.1080/jmf.12.1.50.58

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…Regarding gestational age and chorionicity, Mackenzie performed amniocentesis in 92 pairs of diamniotic twins and found that at extremes of gestational age (28, 29, 36 and 37 weeks), twins were 100% concordant in lung status, while lung concordance was significantly lower in twins of 33–35.9 weeks, and even lower at 30–32.9 weeks. The influence of chorionicity, estimated fetal weight discordance and fetal gender concordance were not predictive of lung maturity 22 . In a study including 42 pairs of twins, Leveno et al reported a high correlation between lecithin/sphingomyelin (L/S) ratios between twins A and B which was not related to birth order, infant sex, birthweight discordance, or zygosity 23 .…”

Section: Discussionmentioning

confidence: 81%

“…The main strength of this study is first, the fact that a non-invasive technique was used to evaluate the individualized risk for NRM for each twin; and secondly, our study included a larger number of pairs than the studies by Leveno et al 23 , Mackenzie 22 and Winn et al 24 , who included no more than 92 pairs of twins. However, some limitations are of note: respiratory morbidity was not clinically addressed immediately after the test.…”

Section: Discussionmentioning

confidence: 99%

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Concordance of the risk of neonatal respiratory morbidity assessed by quantitative ultrasound lung texture analysis in fetuses of twin pregnancies

Moreno-Espinosa

Hawkins-Villarreal

Burgos-Artizzu

et al. 2022

Sci Rep

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To evaluate the concordance of the risk of neonatal respiratory morbidity (NRM) assessed by quantitative ultrasound lung texture analysis (QuantusFLM) between twin fetuses of the same pregnancy. Prospective study conducted in twin pregnancies. Fetal ultrasound lung images were obtained at 26.0–38.6 weeks of gestation. Categorical (high or low) and continuous results of the risk of NRM were compared between twins. Fetal ultrasound lung images from 131 pairs (262 images) of twins were included. The images were classified into three gestational age ranges: Group 1 (26.0–29.6 weeks, 78 images, 39 pairs [29.8%]); Group 2 (30.0–33.6 weeks, 98 images, 49 pairs [37.4%]) and Group 3 (34.0–38.6 weeks, 86 images, 43 pairs [32.8%]). Concordance was good in Groups 1 and 3 and moderate in Group 2. In Groups 2 and 3 at least one fetus presented high-risk results in 26.5% and 11.6% of twin pairs, respectively. Only gestational age < 32 weeks, gestational diabetes mellitus, and spontaneous conception were associated with a high risk of NRM in Group 2. There was good concordance of the risk of NRM between twins < 30.0 weeks and > 34.0 weeks. From 30.0 to 33.6 weeks 26.5% of the twin pairs had discordant results, with moderate concordance of the risk of NRM.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Concordance of the risk of neonatal respiratory morbidity assessed by quantitative ultrasound lung texture analysis in fetuses of twin pregnancies

Moreno-Espinosa

Hawkins-Villarreal

Burgos-Artizzu

et al. 2022

Sci Rep

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“…Publications on NRM and its prediction in twin pregnancies are scarce and present mixed outcomes, with twin pregnancies frequently being an exclusion criterion to evaluate results in diagnostic tests. Some studies have evaluated fetal lung maturity in twin pregnancies [ 18 , 19 , 20 ]; however, none of these studies have focused on predicting NRM or reporting the performance of the tests used. We hypothesized that the performance of quantusFLM ® in predicting NRM in neonates from twin pregnancies would be comparable to that previously reported in the general population.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies

Moreno-Espinosa

Hawkins-Villarreal

Coronado-Gutiérrez

et al. 2022

JCM

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The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM® version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM® in predicting NRM was analyzed by matching quantitative ultrasound analysis and clinical outcomes. This study included 166 images. Neonatal respiratory morbidity occurred in 12.7% of cases, and it was predicted by quantusFLM® analysis with an overall sensitivity of 42.9%, specificity of 95.9%, positive predictive value of 60%, and negative predictive value of 92.1%. The accuracy was 89.2%, with a positive likelihood ratio of 10.4, and a negative likelihood ratio of 0.6. The results of this study demonstrate the good prediction capability of NRM in twin pregnancies using a non-invasive lung texture analysis software. The test showed an overall good performance with high specificity, negative predictive value, and accuracy.

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Fetal Lung Maturity

Gabbe

Poggi

Ghidini

2007

Management of High‐Risk Pregnancy

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Predicting concordance of biochemical lung maturity in the preterm twin gestation

Cited by 10 publications

References 15 publications

Concordance of the risk of neonatal respiratory morbidity assessed by quantitative ultrasound lung texture analysis in fetuses of twin pregnancies

Concordance of the risk of neonatal respiratory morbidity assessed by quantitative ultrasound lung texture analysis in fetuses of twin pregnancies

Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies

Fetal Lung Maturity

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