Predicting chemoradiotherapy response of nasopharyngeal carcinoma using texture features based on intravoxel incoherent motion diffusion-weighted imaging

Abstract

The aim of the study was to investigative the utility of gray-level co-occurrence matrix (GLCM) texture analysis based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for predicting the early response to chemoradiotherapy for nasopharyngeal carcinoma (NPC).Baseline IVIM-DWI was performed on 81 patients with NPC receiving chemoradiotherapy in a prospective nested case–control study. The patients were categorized into the residue (n = 11) and nonresidue (n = 70) groups, according to whether there was local residual lesion or not at the end of chemoradiotherapy. The pretreatment tumor volume and the values of IVIM-DWI parameters (apparent diffusion coefficient [ADC], D, D∗, and f) and GLCM features based on IVIM-DWI were compared between the 2 groups. Receiver operating characteristic (ROC) curves in univariate and multivariate logistic regression analysis were generated to determine significant indicator of treatment response.The nonresidue group had lower tumor volume, ADC, D, CorrelatADC, CorrelatD, InvDfMomADC, InvDfMomD and InvDfMomD∗ values, together with higher ContrastD, Contrastf, SumAvergADC, SumAvergD, and SumAvergD∗ values, than the residue group (all P < .05). Based on ROC curve in univariate analysis, the area under the curve (AUC) values for individual GLCM features in the prediction of the treatment response ranged from 0.635 to 0.879, with sensitivities from 54.55% to 100.00% and specificities from 52.86% to 85.71%. Multivariate logistic regression analysis demonstrated D (P = .026), InvDfMomADC (P = .033) and SumAvergD (P = .015) as the independent predictors for identifying NPC without residue, with an AUC value of 0.977, a sensitivity of 90.91% and a specificity of 95.71%.Pretreatment GLCM features based on IVIM-DWI, especially on the diffusion-related maps, may have the potential to predict the early response to chemoradiotherapy for NPC.

Texture analysis for chemotherapy response evaluation in osteosarcoma using MR imaging

“…To the best of our knowledge there is no study related to statistical TA on IVIM DWI parametric maps for evaluating chemotherapeutic response in osteosarcoma. Prior studies analyzing GLCM features in IVIM DWI parametric maps of locally advanced rectal cancer 30 and nasopharyngeal carcinoma 31 baseline was associated with a better response to chemoradiotherapy. Therefore, statistical textural features quantifying significantly low perfusion and lower angiogenic heterogeneity in tumor might be potential markers of chemoresistance and poor outcome among patients with osteosarcoma at the time of presentation.…”

“…However, textural features are sensitive to image acquisition parameters used in different protocols and to intra‐ and inter‐scanner variations in the case of MRI 49 . To solve this problem, gray‐level normalization filter dynamics limited to μ ± 3 σ , proposed by Collewet et al 44 and supported by prior studies 30,31 performing TA using IVIM‐DWI data, were applied before TA. TA was applied to functional parametric maps as these are in absolute units and unbiased by the scanner and acquisition protocols used.…”

“…Recently, texture analysis (TA) 19 of MR images has shown promising results in evaluating the response to therapy in different types of cancers 20,21 such as brain, 22 breast, [23][24][25] bone, [26][27][28] rectum, 29,30 nasopharynx 31 and soft tissue sarcoma. 32 TA uses mathematical formulae to characterize the spatial distribution of signal intensity variations in an image and evaluate its quantitative parameters.…”

Diffusion-weighted MRI for predicting treatment response in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

“…However, conventional MRI has limitations regarding the early prediction of treatment response in NPC 5 . Advanced imaging techniques, including DWI and perfusion imaging, are usually applied for the evaluation of treatment response and residual or recurred tumor 6 .…”

Chemotherapy Potentially Facilitates the Occurrence of Radiation Encephalopathy in Patients With Nasopharyngeal Carcinoma Following Radiotherapy: A Multiparametric Magnetic Resonance Imaging Study

“…Nasopharyngeal carcinoma (NPC) is a malignancy arising from the epithelium of the nasopharynx and is prevalent in southern China (1–3). Radiotherapy (RT) with or without chemotherapy is the primary treatment for patients with NPC (4); however, despite considerable improvements in RT techniques and chemotherapy regimens for patients with NPC, treatment-related complications are still not uncommon in routine clinical practice.…”