“…Risk factors for BM in NSCLC reported previously comprise: Age(9)(10)(11), gender (11), non-squamous cell carcinoma/ adenocarcinoma(9)(12)(13)(11), clinical stage (13), number of extracranial metastases(10), malignant pleural effusion(10), nodal involvement (12), EGFRm or ALKr(13)( 14), high CEA(8), neutrophil-lymphocyte ratio (15), elevated neuro-speci c enolase (9),and high CA125 (9), with the exception of the latest two, all were analyzed in the present study. Although several clinical markers have been explored, no adequate model has a proven capability of predicting which patients with NSCLC will have BM (5) or failing to identify a group who would bene t from prophylactic cranial irradiation as a measure of extending overall survival (16), there is a window of opportunity exploring molecular markers (7). Previous authors have de ned a high-risk group for BM according to particular characteristics, to mention some: a) Age < 70 years, adenocarcinoma or large cell histology, tumor size > 3 cm, tumor grade ≥ II, and node positive disease(6), b) Adenocarcinoma, EGFRm + or ALKr + and CEA > 20 pg/mL (8).…”