Predicting anxiety and depression from personality: Is there a synergistic effect of neuroticism and extraversion?

Jorm, Anthony F; Christensen, Helen; As, Henderson; Pa, Jacomb; Korten, A. E.; Rodgers, Bryan

doi:10.1037//0021-843x.109.1.145

Cited by 34 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, the moderation analysis reveals that Extraversion does play a role in influencing how Readiness to Change (M) impacts Flourishing under Job Stress, while Neuroticism does not have a significant moderating effect. Hence, the indices of partial moderated mediation were statistically significant for Extraversion (b = 0.0204; BootSE = 0.0091; BootLLCI = 0.0024; Boot ULCI = 0.0387), but not for Neuroticism (b = 0.0041; BootSE = 0.0076; BootLLCI = −0.0114; Boot ULCI = 0.0190), given that the interval contains zero [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Highest order moderation of extraversion and neuroticism into the relationship between job stress and flourishing: Mediated by readiness to change among Chinese medical teachers

Yan,

Ping,

Feng

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Highest order moderation of extraversion and neuroticism into the relationship between job stress and flourishing: Mediated by readiness to change among Chinese medical teachers

Yan,

Ping,

Feng

et al. 2024

Heliyon

View full text Add to dashboard Cite

Personality Change During Depression Treatment

Tang¹,

DeRubeis²,

Hollon³

et al. 2009

Arch Gen Psychiatry

364

268

View full text Add to dashboard Cite

Background High neuroticism is a personality risk factor that captures much of the genetic vulnerability to Major Depressive Disorder (MDD), and low extraversion may increase risk as well. Both have been linked to the serotonin system. Objectives To test whether MDD patients in selective serotonin reuptake inhibitors (SSRIs) treatment report greater changes in neuroticism and extraversion than patients receiving inert-placebo; and to examine the state-effect hypothesis, that self-reported personality change during SSRI treatment is merely a change of depression-related measurement bias. Design/Setting Personality was measured during a placebo-controlled trial in research clinics. Patients Adult moderate-to-severe MDD patients randomized to receive paroxetine (n=120), placebo (n=60), or cognitive therapy (CT) (n=60). Outcome Measures NEO Five-Factor Inventory; Hamilton Rating Scale for Depression. Results Paroxetine patients reported greater personality change than did placebo patients, even after controlling for depression improvement (p≤.002). The advantage of paroxetine over placebo in antidepressant efficacy was no longer significant after controlling for change in personality (p≥.14). Paroxetine patients reported 6.8 times as much change on neuroticism and 3.5 times as much change on extraversion as placebo patients matched for depression improvement. Although placebo patients exhibited substantial depression improvement (−1.2 SD, p<.001), they reported little change on neuroticism (−0.18 SD, p=.08) or extraversion (0.08 SD, p=.50). CT produced greater personality change than placebo (p≤.01); but its advantage on neuroticism was no longer significant after controlling for depression (p=.14). Neuroticism reduction during treatment predicted lower relapse rates among paroxetine responders (p=.003), but not among CT responders (p=.86). Conclusion Paroxetine appears to have a specific pharmacological effect on personality that is distinct from its effect on depression. If replicated, this pattern would disconfirm the state-effect hypothesis and instead support the notion that SSRIs’ effects on personality go beyond and perhaps contribute to their antidepressant effects.

show abstract