Predicting and Measuring the Sequence Distribution of Condensation Polymers

Montaudo, Maurizio S.

doi:10.1007/978-1-4419-6800-5_11

Cited by 2 publications

(1 citation statement)

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“…MS is a powerful technique for the chemical characterization of polymers and excellent reviews have been written 20–24 . Matrix assisted laser desorption ionization mass spectrometry (MALDI‐MS) and electrospray ionization mass spectrometry (ESI‐MS) are the most prominent ionization techniques used for MS for polymer research 25 .…”

Section: Introductionmentioning

confidence: 99%

Sequence distribution determination by SWAMP‐MS a systematic way of analyzing multiple fragmented polymers with mass spectrometry

Mengerink

Philipsen

Jordens

et al. 2023

J of Applied Polymer Sci

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A new method to determine the blockiness and especially the block length distribution (BLD) of copolymers is described. This Systematic Workflow to Analyze Multi-fragmented Polymers with Mass Spectrometry (SWAMP-MS) is developed to characterize the sequence distribution of synthetic polymers.Copolymerization of polyamide 4,6 and polyamide 4,10 is used as a model system. Supercharged polymer ions, generated by electrospray ionization, swamp the mass spectrum due to <1> different chemical related distributions (chain composition, end groups), <2> the number of repeating units, <3> the charge and adduct distribution, and <4> isotopes distribution. Without selecting specific substrate ions, MSMS will transform this total ion-SWAMP into chemical rich information of the polymer backbone. The generated fragments contain up to 20 monomers. The reduction of blockiness is evaluated by the decreasing abundancy of specific ions originating from the starting polymers. Moreover, evaluation of all significant fragments and applying Monte Carlo simulations can rebuild the polymer backbone and generate sequence distributions of the copolymerized samples, which is currently still a holy grail in co-chemical polymer analysis.

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Section: Introductionmentioning

confidence: 99%