Predicting adherence of dose–volume constraints for personalized partial-breast irradiation technique

Sato, Kazuhiko; Shimo, Takahiro; Fuchikami, Hiromi; Takeda, Naoko; Kato, Masahiro; Okawa, Tomohiko

doi:10.1016/j.brachy.2020.06.018

Cited by 6 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PTV expansion is more limited by the organs at risk than in patients with larger breasts. 39 Finally, the most modern EBRT technique may reduce the PTV margin. Further clinical research is required.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Delineation Accuracy of Lumpectomy Cavity on Planning Target Volume in Partial-Breast Irradiation Using Brachytherapy and External-Beam Radiotherapy

Sato¹,

Shimo²,

Natsume³

et al. 2022

Arch Breast Cancer

View full text Add to dashboard Cite

Background: In partial-breast irradiation (PBI), the accurate target volume delineation based on the lumpectomy cavity (LC) remained difficult due to uncertain LC identification. However, the impact of accurate LC delineation on the planning target volume (PTV) has not been investigated. Material and Methods: Between September 2018 and April 2020, 159 patients receiving perioperative PBI with multicather-interstitial brachytherapy have been evaluated. While LC delineated using implanted catheters as fiducial markers was used as a reference, conventional LC was virtually delineated on computed tomography with clips. PTV1-cm margin and PTV2-cm margin, which means 1cm and 2cm expansion from LC, were developed and assumed for brachytherapy and external-beam PBI, respectively. The target accuracy and the impact of the delineation accuracy of LC on PTVs were evaluated. The geographic miss index (GMI) and normal tissue index (NTI) were used as accuracy indices and were defined as the percentage of under- and overestimating volume, respectively. Results: The PTV1-cm margin and PTV2-cm margin were significantly larger than the reference volume, 57.9cm3 vs. 37.9cm3 (P<0.001) and 113.2cm3 vs. 93.8cm3 (P<0.001), respectively. The GMI and NTI of LC were 27.3% and 41.2%, respectively. Although the GMI in the PTV1-cm margin and PTV2-cm margin was significantly reduced to 9.8% (P<0.0001) and 9.9% (P<0.0001), respectively, the NTI was not significantly improved in the PTV1-cm margin, which was 41.8% (P=0.60) but was improved in PTV2-cm margin, which was 23.1% (P<0.0001). Conclusion: The GMI in PTV1-cm margin was reduced to be as low as PTV2-cm margin. Although PTV2-cm margin was associated with lower NTI, the absolute volume was almost double with PTV1-cm margin. Although further research was required, brachytherapy-based PBI may be a reasonable option to achieve tumor control and cosmesis using conventional delineation method.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of the Delineation Accuracy of Lumpectomy Cavity on Planning Target Volume in Partial-Breast Irradiation Using Brachytherapy and External-Beam Radiotherapy

Sato¹,

Shimo²,

Natsume³

et al. 2022

Arch Breast Cancer

View full text Add to dashboard Cite

show abstract

Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer

Sato,

Fuchikami,

Takeda

et al. 2024

Breast Cancer

Self Cite

View full text Add to dashboard Cite

Perioperative partial-breast irradiation (PBI) with multicatheter interstitial brachytherapy (MIB) is less invasive and more convenient. This study aimed to compare ultrashort perioperative MIB-PBI and conventional MIB-PBI (cPBI). METHODSThe trial was conducted on patients aged ≥ 40 years and those with T0-2 (≤ 3 cm), N0-mi, and negative margins on mammography. The locoregional recurrence (LRR) and toxicity rates were compared between ultrashort perioperative MIB-PBI (uPBI) at a dose of 25.2 Gy in 4 fractions and cPBI at a dose of 32 Gy in 8 fractions. RESULTSIn total, 198 patients (151 with uPBI and 47 with cPBI) were evaluated. At a median follow-up of 20.1 months, one (0.66%) patient in the uPBI group had LRR. The 2-year ipsilateral breast tumor recurrencefree survival rates of the uPBI and cPBI groups were 98.7% and 100%, respectively. The highest toxicity grades were grade 1 in 23 (15.2%) and grade 2 in 2 (1.3%) patients in the uPBI group, and grade 1 in 8 (17.0%) and grade 2 in 1 (2.1%) patient in the cPBI group. None of the patients in the two groups presented with grade 3 and higher toxicities. The toxicity rates between the two groups did not signi cantly differ. Further, 22 (14.6%) patients in the uPBI group and 8 (17.0%) in the cPBI group, and 3(2.0%) patients in the uPBI group and 1 (2.1%) in the cPBI had acute and late toxicities, respectively.Toxicities commonly occurred at ≤ 3 months after PBI. Nevertheless, the timing of toxicity development between the two groups did not signi cantly differ. CONCLUSIONSThis preliminary report included a small sample size and had a short follow-up period. However, the local control and toxicity rates were similar between the uPBI and cPBI groups. Therefore, an ultrashort hypofraction schedule is feasible and safe for perioperative MIB-PBI.

show abstract

Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer

Sato,

Fuchikami,

Takeda

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

PURPOSE Perioperative partial-breast irradiation (PBI) with multicatheter interstitial brachytherapy (MIB) is less invasive and more convenient. This study aimed to compare ultrashort perioperative MIB-PBI and conventional MIB-PBI (cPBI). METHODS The trial was conducted on patients aged ≥ 40 years and those with T0–2 (≤ 3 cm), N0-mi, and negative margins on mammography. The locoregional recurrence (LRR) and toxicity rates were compared between ultrashort perioperative MIB-PBI (uPBI) at a dose of 25.2 Gy in 4 fractions and cPBI at a dose of 32 Gy in 8 fractions. RESULTS In total, 198 patients (151 with uPBI and 47 with cPBI) were evaluated. At a median follow-up of 20.1 months, one (0.66%) patient in the uPBI group had LRR. The 2-year ipsilateral breast tumor recurrence-free survival rates of the uPBI and cPBI groups were 98.7% and 100%, respectively. The highest toxicity grades were grade 1 in 23 (15.2%) and grade 2 in 2 (1.3%) patients in the uPBI group, and grade 1 in 8 (17.0%) and grade 2 in 1 (2.1%) patient in the cPBI group. None of the patients in the two groups presented with grade 3 and higher toxicities. The toxicity rates between the two groups did not significantly differ. Further, 22 (14.6%) patients in the uPBI group and 8 (17.0%) in the cPBI group, and 3 (2.0%) patients in the uPBI group and 1 (2.1%) in the cPBI had acute and late toxicities, respectively. Toxicities commonly occurred at ≤ 3 months after PBI. Nevertheless, the timing of toxicity development between the two groups did not significantly differ. CONCLUSIONS This preliminary report included a small sample size and had a short follow-up period. However, the local control and toxicity rates were similar between the uPBI and cPBI groups. Therefore, an ultrashort hypofraction schedule is feasible and safe for perioperative MIB-PBI.

show abstract

Predicting adherence of dose–volume constraints for personalized partial-breast irradiation technique

Cited by 6 publications

References 52 publications

Impact of the Delineation Accuracy of Lumpectomy Cavity on Planning Target Volume in Partial-Breast Irradiation Using Brachytherapy and External-Beam Radiotherapy

Impact of the Delineation Accuracy of Lumpectomy Cavity on Planning Target Volume in Partial-Breast Irradiation Using Brachytherapy and External-Beam Radiotherapy

Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer

Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer

Contact Info

Product

Resources

About