Predicted Protein Structure of Medaka<i>FoxA3</i>and Its Expression in Polster

Okamoto, Hiroyuki; Nakayama, Ichiro; Nagoya, Hiroyuki; Araki, Kazuo

doi:10.2108/zsj.18.823

Cited by 2 publications

(3 citation statements)

References 21 publications

(20 reference statements)

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“…In online supplementary figure 1, as expected, all the medaka Fox genes can be classified into 18 subclasses, which were named from OlFoxA to OlFoxR1. However, in this study, we classified the OlFoxA3 (gi21263704) and OlFKH1 (NP_001098163) into groups A2 and A3, respectively, which diverged from published results [Okamoto et al, 2001].…”

Section: Phylogenetic Analysiscontrasting

confidence: 80%

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The Forkhead Gene Family in Medaka: Expression Patterns and Gene Evolution

Shen

Cui²,

Nagahama³

2012

Cytogenet Genome Res

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Using the genome sequence of the medaka, Oryzias latipes, we examined the genomic complement of Fox genes in this organism to gain insight into the evolutionary relationships and expression patterns of this gene family. We identified 31 Fox genes by searching for Forkhead domains in the medaka genome and by polymerase chain reaction (PCR) using primers designed from protein alignments. All the medaka Fox genes are encoded in 18 subclasses as follows: 5 Fox genes in subclass D; 3 Fox genes in subclass O; 2 Fox genes in each of subclass A, B, E, F, G, I, P, and Q, respectively; 1 Fox gene in each of subclass C, H, J, K, M, N, and R. The gene structures and general features are also discussed. In addition, we examined the expression patterns of some of these genes in different adult tissues and during embryonic development in medaka using quantitative PCR and in situ hybridization. The present study shows that Forkhead transcription factors play an important role during early embryonic development in medaka, and the results will enhance our knowledge in terms of Fox family evolution in different taxa.

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Section: Phylogenetic Analysiscontrasting

confidence: 80%

“…Until this study, only 5 Fox genes were characterized in medaka [Okamoto et al, 2001;Li et al, 2007]. In the present study, we set out to identify and classify those Fox genes in medaka in order to study aspects of gene evolution and developmental function of the Fox family of genes in this species.…”

mentioning

confidence: 99%

The Forkhead Gene Family in Medaka: Expression Patterns and Gene Evolution

Shen

Cui²,

Nagahama³

2012

Cytogenet Genome Res

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“…Various teleosts may have different lineage‐specific sets of genes with subfunctions or neofunctions, because the gene degeneration process after genome duplication would have differently affected regulatory genes in each lineage. Thus, it is likely that gene functions differ from those of the homologous genes in mammals in some cases (Wittbrodt et al, 1998, 2002; Force et al, 1999; Rhinn and Brand, 2001; McClintock et al, 2001, 2002) and differ even among teleost fishes (Okamoto et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Morphogenesis and regionalization of the medaka embryonic brain

Kage

Takeda

Yasuda³

et al. 2004

J of Comparative Neurology

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We examined the morphogenesis and regionalization of the embryonic brain of an acanthopterygian teleost, medaka (Oryzias latipes), by in situ hybridization using 14 gene probes. We compared our results with previous studies in other vertebrates, particularly zebrafish, an ostariophysan teleost. During the early development of the medaka neural rod, three initial brain vesicles arose: the anterior brain vesicle, which later developed into the telencephalon and rostral diencephalon; the intermediate brain vesicle, which later developed into the caudal diencephalon, mesencephalon, and metencephalon; and the posterior brain vesicle, which later developed into the myelencephalon. In the late neural rod, the rostral brain bent ventrally and the axis of the brain had a marked curvature at the diencephalon. In the final stage of the neural rod, ventricles began to develop, transforming the neural rod into the neural tube. In situ hybridization revealed that the brain can be divided into three longitudinal zones (dorsal, intermediate, and ventral) and many transverse subdivisions, on the basis of molecular expression patterns. The telencephalon was subdivided into two transverse domains. Our results support the basic concept of neuromeric models, including the prosomeric model, which suggests the existence of a conserved organization of all vertebrate neural tubes. Our results also show that brain development in medaka differs from that reported in other vertebrates, including zebrafish, in gene-expression patterns in the telencephalon, in brain vesicle formation, and in developmental speed. Developmental and genetic programs for brain development may be somewhat different even among teleosts.

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Predicted Protein Structure of MedakaFoxA3and Its Expression in Polster

Cited by 2 publications

References 21 publications

The Forkhead Gene Family in Medaka: Expression Patterns and Gene Evolution

The Forkhead Gene Family in Medaka: Expression Patterns and Gene Evolution

Morphogenesis and regionalization of the medaka embryonic brain

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