Predicted normal values for maximal respiratory pressures in caucasian adults and children.

Wilson, Stephen; Cooke, N. J.; Edwards, R. H. T.; Spiro, Stephen

doi:10.1136/thx.39.7.535

Cited by 602 publications

(549 citation statements)

References 7 publications

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“…We found that mean maximal inspiratory and expiratory static pressures were low in A-T adolescents when compared to published normal predicted values in children. 21 In our population the low maximal inspiratory and expiratory pressures may reflect decreased muscle mass. Prior studies in healthy individuals have shown that adolescent males generally have higher PI max and PE max values compared to females 21,22 and that this difference was secondary to greater muscle mass following puberty.…”

Section: Discussionmentioning

confidence: 73%

“…21 In our population the low maximal inspiratory and expiratory pressures may reflect decreased muscle mass. Prior studies in healthy individuals have shown that adolescent males generally have higher PI max and PE max values compared to females 21,22 and that this difference was secondary to greater muscle mass following puberty. 22 Although our sample size was small we found no difference in PI max or PE max values between genders.…”

Section: Discussionmentioning

confidence: 73%

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Pulmonary function in adolescents with ataxia telangiectasia

McGrath‐Morrow¹,

Lefton‐Greif²,

Rosquist³

et al. 2007

Pediatric Pulmonology

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Summary. Introduction. Pulmonary complications are common in adolescents with ataxia telangiectasia (A-T), however objective measurements of lung function may be difficult to obtain because of underlying bulbar weakness, tremors, and difficulty coordinating voluntary respiratory maneuvers. To increase the reliability of pulmonary testing, minor adjustments were made to stabilize the head and to minimize leaks in the system. Fifteen A-T adolescents completed lung volume measurements by helium dilution. To assess for reproducibility of spirometry testing, 10 A-T adolescents performed spirometry on three separate occasions. Results. Total lung capacity (TLC) was normal or just mildly decreased in 12/15 adolescents tested. TLC correlated positively with functional residual capacity (FRC), a measurement independent of patient effort (R 2 ¼ 0.71). The majority of individuals had residual volumes (RV) greater than 120% predicted (10/15) and slow vital capacities (VC) less than 70% predicted (9/15). By spirometry, force vital capacity (FVC) and forced expiratory volume in 1 sec (FEV 1 ) values were reproducible in the 10 individuals who underwent testing on three separate occasions (R ¼ 0.97 and 0.96 respectively). Seven of the 10 adolescents had FEV 1 /FVC ratios >90%. Conclusion. Lung volume measurements from A-T adolescents revealed near normal TLC values with increased RV and decreased VC values. These findings indicate a decreased ability to expire to residual volume rather then a restrictive defect. Spirometry was also found to be reproducible in A-T adolescents suggesting that spirometry testing may be useful for tracking changes in pulmonary function over time in this population.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Pulmonary function in adolescents with ataxia telangiectasia

McGrath‐Morrow¹,

Lefton‐Greif²,

Rosquist³

et al. 2007

Pediatric Pulmonology

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“…Their baseline mean age was 9.4 years and mean 6MWT distance at baseline was 363.2m (Table 4). Mean pulmonary function tests (MIP, MEP, and FVC percentage of predicted) at baseline were within normal ranges34 (see Table 2). …”

Section: Resultsmentioning

confidence: 80%

“…Up to 5 efforts were allowed, and the best effort results were used for analysis. Results were converted to percentage of predicted values employing the widely used methodologies of Wilson et al34 for MIP and MEP and Polgar and Varuni35 for FVC.…”

Section: Methodsmentioning

confidence: 99%

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

Mendell

Goemans²,

Lowes

et al. 2016

Annals of Neurology

445

392

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ObjectiveTo continue evaluation of the long‐term efficacy and safety of eteplirsen, a phosphorodiamidate morpholino oligomer designed to skip DMD exon 51 in patients with Duchenne muscular dystrophy (DMD). Three‐year progression of eteplirsen‐treated patients was compared to matched historical controls (HC).MethodsAmbulatory DMD patients who were ≥7 years old and amenable to exon 51 skipping were randomized to eteplirsen (30/50mg/kg) or placebo for 24 weeks. Thereafter, all received eteplirsen on an open‐label basis. The primary functional assessment in this study was the 6‐Minute Walk Test (6MWT). Respiratory muscle function was assessed by pulmonary function testing (PFT). Longitudinal natural history data were used for comparative analysis of 6MWT performance at baseline and months 12, 24, and 36. Patients were matched to the eteplirsen group based on age, corticosteroid use, and genotype.ResultsAt 36 months, eteplirsen‐treated patients (n = 12) demonstrated a statistically significant advantage of 151m (p < 0.01) on 6MWT and experienced a lower incidence of loss of ambulation in comparison to matched HC (n = 13) amenable to exon 51 skipping. PFT results remained relatively stable in eteplirsen‐treated patients. Eteplirsen was well tolerated. Analysis of HC confirmed the previously observed change in disease trajectory at age 7 years, and more severe progression was observed in patients with mutations amenable to exon skipping than in those not amenable. The subset of patients amenable to exon 51 skipping showed a more severe disease course than those amenable to any exon skipping.InterpretationOver 3 years of follow‐up, eteplirsen‐treated patients showed a slower rate of decline in ambulation assessed by 6MWT compared to untreated matched HC. Ann Neurol 2016;79:257–271

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“…Of these 33 articles, only eight describe the type of mouth piece, 11 describe the presence and size of a pressure relief port, varying from 0.5 to 1.8 mm, and 11 report the minimum time of respiratory effort. Eight of 33 applied predictive equations to the analysis, five used Black and Hyatt, 17 two Wilson et al, 18 and one Rochester,19 with the rest considering only the absolute values.…”

Section: Discussionmentioning

confidence: 99%

Maximal static mouth respiratory pressure in spinal cord injured patients: correlation with motor level

2006

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Study design: Transversal. Objectives: The few studies concerning maximal static mouth respiratory pressures in patients with spinal cord lesions suggest a marked reduction. We studied the correlation of these parameters with the motor level of injury. Setting: Rehabilitation Center, Brası´lia/DF, Brazil. Methods: One hundred and thirty-one patients with traumatic spinal cord injury (C4-L3) were recruited. The participants were assessed by standard spirometry and maximal static mouth respiratory pressure. Results: Forced vital capacity was most reduced in tetraplegics (subgroup C4-C5, 49%725 predicted) and increase successively for each descending subgroup (C6-C8, 61%722 predicted; T1-T6, 70%715 predicted), becoming normal in low paraplegia (T7-L3, 84%715 predicted). There is no evidence of an obstructive disturbance throughout all groups. The lowest average percent predicted of maximal static inspiratory pressure (MIP) was in the subgroup C4-C5 (50%723). The average percent predicted of maximal static expiratory pressure (MEP) improved from 19%714 in the C4-C5 subgroup to 51%719 for T7-L3 subgroup. The average percent predicted of all participants for MIP was 74%730 and for MEP was 37%721. In patients with complete motor lesion, the correlation with the level of injury was stronger for MEP (r ¼ 0.81, Po0.0001; r 2 ¼ 0.65) than for MIP (r ¼ 0.62, P ¼ 0.004; r 2 ¼ 0.38). No correlation was found among incomplete motor lesion patients. Conclusions: The linear regression equations for the relationship of percent predicted MIP or MEP to level of injury are applicable only to complete motor lesions and may be useful to establish normative association between them.

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Predicted normal values for maximal respiratory pressures in caucasian adults and children.

Cited by 602 publications

References 7 publications

Pulmonary function in adolescents with ataxia telangiectasia

Pulmonary function in adolescents with ataxia telangiectasia

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

Maximal static mouth respiratory pressure in spinal cord injured patients: correlation with motor level

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