Predicted efficacy and tolerance of different dosage regimens of benzylpenicillin in horses based on a pharmacokinetic study with three IM formulations and one IV formulation
Aude A. Ferran,
Béatrice B. Roques,
Laura Chapuis
et al.
Abstract:IntroductionBenzylpenicillin (BP) is a first-line antibiotic in horses but there are discrepancies between manufacturers and literature recommendations regarding dosing regimen. Objectives of this study were to evaluate pharmacokinetics and local tolerance of four different formulations of BP in adult horses, and to suggest optimized dosing regimen according to the formulation.MethodsA cross-over design was used in 3 phases for the intramuscular injection of three different products: procaine BP alone, procain… Show more
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