Predictable stress versus unpredictable stress: A comparison in a rodent model of stroke

Zucchi, Fabíola Cristina Ribeiro; Kirkland, Scott W.; Jadavji, Nafisa M.; Waes, Luuk Van; Klein, Alexander; Supina, Rebecca D.; Metz, Gerlinde A. S.

doi:10.1016/j.bbr.2009.06.030

Cited by 30 publications

(22 citation statements)

References 56 publications

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“…The stress- and CORT-induced motor deficits shown here confirm previous studies of diminished reaching success and movement scores [20,22,23]. Appropriate changes in plasma CORT and glucose also confirm the salience of the present manipulations.…”

Section: Discussionsupporting

confidence: 77%

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Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Jadavji

Supina²,

Metz³

2011

Neuroendocrinology

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Aim: Stress and glucocorticoids can influence movement performance and pathologies of the motor system. The classic notion assumes that the glucocorticoid receptor (GR) mediates the majority of stress-induced behavioral changes. Nevertheless, recent findings have attributed a more prominent role to the mineralocorticoid receptor (MR) in modulating behavior. The purpose of this study was to dissociate the impact of MR versus GR activation in movement and stress-associated motor disruption. Methods: Groups of male and female rats were tested in skilled reaching and open field behavior and treated peri-orally with either agonists or antagonists for MR and GR, respectively. Results: Selective acute activation of MR (aldosterone) and GR (dexamethasone) decreased movement success with a magnitude similar to stress-induced impairment in male and female animals. By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment. Moreover, both antagonists reversed chronic stress- and glucocorticoid-induced motor impairments to values comparable to baseline levels. Higher success rates in treated animals were accompanied by improved performance of skilled limb movements. In addition, combined treatment with MR and GR antagonists had additive benefit on aim and advance towards the reaching target. Conclusion: These observations suggest that MR or GR equally influence motor system function with partially synergistic effects. Males and females show comparable responses to MR and GR activation or blockade. The need for balanced activation of MRs and GRs in motor control requires consideration in intervention strategies to improve performance in health and disease.

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Section: Discussionsupporting

confidence: 77%

“…Indeed, systemic administration of CORT or stress disturbs skilled and non-skilled movement at both acute and long-term intervals [19,20]. Moreover, motor function seems to be equally impaired by treatment with either stress or CORT [20,21,22,23]. These observations also apply to studies of brain damage.…”

Section: Introductionmentioning

confidence: 67%

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Jadavji

Supina²,

Metz³

2011

Neuroendocrinology

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“…Although animals may show gradual habituation to daily restraint in physiological measures, it nevertheless causes chronically diminished motor deficits [19,22,35]. Similar findings were made in the young animals that displayed a modest increase in circulating CORT levels after three days of restraint and return to baseline levels at chronic time points.…”

Section: Discussionsupporting

confidence: 58%

“…Sustained high levels of glucocorticoids may compromise the ability to overcome ischemia-induced deficits both on the neuronal and functional level [18][19][20][21][22]. Complex physiological changes involving activity of the HPA axis may explain, at least in part, the large variability of stroke recovery among aged individuals.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of age and stress in a rodent model of stroke

Merrett

Kirkland

Metz

2010

Behavioural Brain Research

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Ageing and stress represent critical influences on stroke risk and outcome. These variables are intricately linked, as ageing is frequently associated with gradual dysregulation of the hypothalamic-pituitary-adrenal axis. This study determined the effects of stress on motor function in aged rats, and explored possible interactions of age and stress on motor recovery following stroke in a rat model. Young adult (4 months) and aged (18 months) male Wistar rats were tested in skilled and non-skilled movement before and after focal ischemia in motor cortex. One group of each age received restraint stress starting seven days pre-lesion until three weeks post-lesion. Aged rats were less mobile and stress further diminished their overall exploratory activity. Aged rats were also less proficient in motor skill acquisition and slower to improve after lesion. Stress diminished post-lesion improvement and prevented recovery of endpoint measures. The larger functional loss in aged rats vs. young rats was accompanied by greater damage of cortical tissue and persistent elevations in corticosterone levels. The behavioural and physiological measures suggest limited ability of aged animals to adapt to chronic stress. These findings show that age or stress alone can modulate motor performance but may have greater influence by synergistically affecting stroke recovery.

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“…El estrés también supone complicaciones a nivel del sistema inmunitario, enlenteciendo los procesos de curación, disminuyendo la respuesta inmune a vacunas, aumentando la vulnerabilidad ante agentes infecciosos y aumentando las posibilidades de reactivación de virus latentes (Herbert, Cohen, Miller, 2001;Cohen, 2005;Glaser, Kiecolt-Glaser, 2005;Sagerstroom, Miller, 2007); a nivel cardiovascular, aumentando el riesgo de accidentes cardiovasculares y cerebrovasculares (Friedman, Rosenman, 1974;Meerson, 1994;Pickering, 2004;Janicki-Deverts, Cohen, Matthews, Cullen, 2008;Zucchi, Kirkland, Jadavji, van Waes, Klein, Supina, Metz, 2009); a nivel metabólico incrementando el riesgo de diabetes tipo 2 y el riesgo de desarrollar el síndrome metabó-lico (Cohen, Manuck, 1995;Surwit, Williams, 1996;Vitaliano, Scanlan, Zhang, Savage, Hirsch, Siegler, 2002); a nivel gastrointestinal, aumentando el riesgo de úlceras y síndrome del colon irritable (Brady, Porter, Conrad, Mason, 1958;Bennett, Tennant, Piesse, 1998;Mayer, 2000) e incluso en qué y cuánto comer (Dallman, Prcoraro, Akana, Fleur, Gómez, Houshyar, Bhatnagar, Laurgero, Manalo, 2003;Adam, Epel, 2007).…”

Section: Introductionunclassified

Análisis de variables psicológicas asociadas a la salud y productividad en la universidad

Ruisoto

Vaca²,

Jimenez

et al. 2015

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RESUMENEl consumo de sustancias adictivas y los problemas de ansiedad y depresión constituyen algunos de las complicaciones de la salud más frecuentes en la población, con serios costes para su bienestar y la productividad de la comunidad o institución a la que pertenecen. Se presenta un proyecto dirigido a analizar la distribución del estrés percibido y variables que modulan su impacto sobre la salud de la comunidad universitaria, incluyendo inflexibilidad psicológica y compromiso vital, predictores de bienestar psicológico. Se seleccionaron variables y escalas breves y adecuadas psicométricamente para la evaluación online anónima de profesores, estudiantes y personal de administración y servicios. Las variables seleccionadas fueron: estrés psicológico y variables mediadoras de su impacto sobre el consumo de sustancias y la salud: apoyo social, personalidad y estilos de afrontamiento. Los indicadores criterio de salud fueron: niveles de ansiedad y depresión, consumo de sustancias y satisfacción vital y laboral. El proyecto permitirá obtener perfiles que reflejen la distribución de las variables analizadas en la comunidad universitaria. Se discuten las implicaciones de los resultados esperados en el diseño y priorización de intervenciones dirigidas a la promoción de la salud, bienestar y productividad de la comunidad universitaria.PALABRAS CLAVE: estrés, salud, consumo de sustancias, ansiedad, depresión, inflexibilidad psicológica, compromiso vital, comunidad universitaria. ABSTRACTBoth substance abuse and anxiety/depression disorders are among the most common health complications with serious costs for welfare and productivity of the community or institution to which they belong. This study presents a project aimed to analyze the distribution of perceived stress and variables that modulate its impact on the health at the university community, including life-engagement, psychological inflexibility and predictors of psychological well-being. Key variables and scales for their measurement were carefully selected according to their psychometric properties and application time for the online and anonymous evaluation of faculty, students and administrative staff and services. Target variables were the following: psychological stress, social support, personality and coping styles. The following health indicators were: levels of anxiety and depression, substance consumption, and life/job satisfaction. The project will provide profiles regarding the distribution of analyzed variables in the university community. Implications of those profiles for the design and prioritization of interventions aimed to promote health, welfare and productivity of the university community are further discussed.

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Predictable stress versus unpredictable stress: A comparison in a rodent model of stroke

Cited by 30 publications

References 56 publications

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Synergistic effects of age and stress in a rodent model of stroke

Análisis de variables psicológicas asociadas a la salud y productividad en la universidad

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