Predictable regulation of survival by intratumoral microbe-immune crosstalk in patients with lung adenocarcinoma
Shuo Shi,
Yuwen Chu,
Haiyan Liu
et al.
Abstract:Intratumoral microbiota can regulate the tumor immune microenvironment (TIME) and mediate tumor prognosis by promoting inflammatory response or inhibiting anti-tumor effects. Recent studies have elucidated the potential role of local tumor microbiota in the development and progression of lung adenocarcinoma (LUAD). However, whether intratumoral microbes are involved in the TIME that mediates the prognosis of LUAD remains unknown. Here, we obtained the matched tumor microbiome and host transcriptome and surviva… Show more
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