Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

Suo, Lin; Zhao, Liyan; Si, Jijian; Liu, Jianfeng; Zhu, Weili; Chai, Bai-Sheng; Zhang, Yan; Feng, Jiajia; Ding, Zhixia; Luo, Yunping; Shi, Haishui; Shi, Jie; Lü, Lin

doi:10.1038/npp.2013.67

Cited by 112 publications

(111 citation statements)

References 50 publications

(80 reference statements)

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“…For this two-bottle choice test (Bolanos, Barrot, Berton, Wallace-Black, & Nestler, 2003), one bottle was filled with 1% sucrose solution and the other filled with water and both were then placed in the cage as described previously (Suo et al, 2013).…”

Section: Sucrose Preference Testmentioning

confidence: 99%

“…The elevated plus maze (EPM) is based on a rat's natural fear of open, unprotected and elevated spaces (Suo et al, 2013). Each rat was first placed in the central zone of the EPM with its head oriented to the closed arm.…”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

“…Each rat was first placed in the central zone of the EPM with its head oriented to the closed arm. The rat was allowed to freely explore the maze for 5 min as described previously (Franceschelli, Sens, Herchick, Thelen, & Pitychoutis, 2015;Suo et al, 2013) …”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

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Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

et al. 2017

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Section: Sucrose Preference Testmentioning

confidence: 99%

Section: Elevated Plus Maze Testmentioning

confidence: 99%

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Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

et al. 2017

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“…The elevated plus maze was based on our previous studies (Suo et al, 2013;Xue et al, 2015). Briefly, each rat was placed in the central zone of the elevated plus maze.…”

Section: Elevated Plus Mazementioning

confidence: 99%

AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation

Han

Luo

Sun

et al. 2015

Neuropsychopharmacol

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Both the formation of long-term memory (LTM) and dendritic spine growth that serves as a physical basis for the long-term storage of information require de novo protein synthesis. Memory formation also critically depends on transcription. Adenosine monophosphateactivated protein kinase (AMPK) is a transcriptional regulator that has emerged as a major energy sensor that maintains cellular energy homeostasis. However, still unknown is its role in memory formation. In the present study, we found that AMPK is primarily expressed in neurons in the hippocampus, and then we demonstrated a time-dependent decrease in AMPK activity and increase in mammalian target of rapamycin complex 1 (mTORC1) activity after contextual fear conditioning in the CA1 but not CA3 area of the dorsal hippocampus. Using pharmacological methods and adenovirus gene transfer to bidirectionally regulate AMPK activity, we found that increasing AMPK activity in the CA1 impaired the formation of long-term fear memory, and decreasing AMPK activity enhanced fear memory formation. These findings were associated with changes in the phosphorylation of AMPK and p70s6 kinase (p70s6k) and expression of BDNF and membrane GluR1 and GluR2 in the CA1. Furthermore, the prior administration of an mTORC1 inhibitor blocked the enhancing effect of AMPK inhibition on fear memory formation, suggesting that this negative regulation of contextual fear memory by AMPK in the CA1 depends on the mTORC1 signaling pathway. Finally, we found that AMPK activity regulated hippocampal spine growth associated with memory formation. In summary, our results indicate that AMPK is a key negative regulator of plasticity and fear memory formation.

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“…Chronic mild, predictable stress also causes increased glutamate release but also results in EAAT2 upregulation [227][228][229][230]. This likely accounts for the fact that predictable stress has beneficial effects on depressiveand anxiety-like behaviors [231,232]. On the other hand, chronic, unpredictable stress reduces EAAT2 expression which is a similar phenomenon observed in MDD patients [215,216,233,234].…”

Section: Major Depressive Disordermentioning

confidence: 78%

Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

Takahashi

Foster

Lin

2015

Cell. Mol. Life Sci.

145

111

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Glutamate is the predominant excitatory neurotransmitter in the central nervous system. Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of extracellular glutamate to prevent neuronal excitotoxicity and hyperexcitability. EAAT2 plays a critical role in regulation of synaptic activity and plasticity. In addition, EAAT2 has been implicated in the pathogenesis of many central nervous system disorders. In this review, we summarize current understanding of EAAT2, including structure, pharmacology, physiology, and functions, as well as disease relevancy, such as in stroke, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, Alzheimer's disease, major depressive disorder, and addiction. A large number of studies have demonstrated that up-regulation of EAAT2 protein provides significant beneficial effects in many disease models suggesting EAAT2 activation is a promising therapeutic approach. Several EAAT2 activators have been identified. Further understanding of EAAT2 regulatory mechanisms could improve development of drug-like compounds that spatiotemporally regulate EAAT2.

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Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

Cited by 112 publications

References 50 publications

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation

Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

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