Predictability of Painful Stimulation Modulates the Somatosensory-Evoked Potential in the Rat

Schaap, M.W.H.; Oostrom, Hugo van; Doornenbal, Arie; Baars, Annemarie M.; Arndt, Saskia S.; Hellebrekers, L.J.

doi:10.1371/journal.pone.0061487

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…One potential example relates to the observation that the shock-only group has greater (but not significantly greater) Fos induction than the fear conditioning group. If it proves to be significant, it is possible this greater induction could be a consequence of the unpredictability of painful stimuli, since unpredictability is a potent pain modulator that can influence neuronal activity throughout the brain (Carlsson et al 2006;Oka et al 2010;Schaap et al 2013). Precise estimates of our statistical power and how it relates to the magnitude of expected changes are difficult to estimate, but more automated methods should soon enable type II error to be dramatically reduced.…”

Section: Discussionmentioning

confidence: 99%

Brain-wide maps of Fos expression during fear learning and recall

2017

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induction during learning labels neuronal ensembles in the hippocampus that encode a specific physical environment, revealing a memory trace. In the cortex and other regions, the extent to which induction during learning reveals specific sensory representations is unknown. Here we generate high-quality brain-wide maps of mRNA expression during auditory fear conditioning and recall in the setting of the home cage. These maps reveal a brain-wide pattern of induction that is remarkably similar among fear conditioning, shock-only, tone-only, and fear recall conditions, casting doubt on the idea that reveals auditory-specific sensory representations. Indeed, novel auditory tones lead to as much gene induction in visual as in auditory cortex, while familiar (nonconditioned) tones do not appreciably induce anywhere in the brain. expression levels do not correlate with physical activity, suggesting that they are not determined by behavioral activity-driven alterations in sensory experience. In the thalamus, is induced more prominently in limbic than in sensory relay nuclei, suggesting that may be most sensitive to emotional state. Thus, our data suggest that expression during simple associative learning labels ensembles activated generally by arousal rather than specifically by a particular sensory cue.

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Section: Discussionmentioning

confidence: 99%

Brain-wide maps of Fos expression during fear learning and recall

2017

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“…This is the first report of a reduction in amplitude and duration of spinal SEPs induced by a heterotopic counter irritation. SEP amplitude has been associated with pain sensation [9,10]; thus, it should mean a reduction in pain sensation. There are partial similarities to the DNIC process in: (1) it is triggered by noxious stimuli applied to widespread areas of the body; (2) the inhibition outlasts the duration of the noxious stimulus; (3) there is a close relationship between the strength of the diffuse noxious stimulus and the resulting inhibition [19] and; (4) it is diffuse in nature [23].…”

Section: Discussionmentioning

confidence: 99%

“…Cortical somatosensory-evoked potentials activated by high intensity electrical stimuli applied to peripheral tissue have been associated with the processing of noxious stimuli, showing a direct proportion between pain sensation and wave amplitude [9,10]. The spinal somatosensoryevoked potentials (SEP) offer the possibility to evaluate the neuronal network behavior because they are the result from postsynaptic activity of different sets of neurons.…”

Section: Introductionmentioning

confidence: 99%

Noxious mechanical heterotopic stimulation induces inhibition of the spinal dorsal horn neuronal network: analysis of spinal somatosensory-evoked potentials

Meléndez-Gallardo

Eblén-Zajjur

2016

Neurol Sci

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Most of the endogenous pain modulation (EPM) involves the spinal dorsal horn (SDH). EPM including diffuse noxious inhibitory controls have been extensively described in oligoneuronal electrophysiological recordings but less attention had been paid to responses of the SDH neuronal population to heterotopic noxious stimulation (HNS). Spinal somatosensory-evoked potentials (SEP) offer the possibility to evaluate the neuronal network behavior, reflecting the incoming afferent volleys along the entry root, SDH interneuron activities and the primary afferent depolarization. SEP from de lumbar cord dorsum were evaluated during mechanical heterotopic noxious stimuli. Sprague-Dawley rats (n = 12) were Laminectomized (T10-L3). The sural nerve of the left hind paw was electrically stimulated (5 mA, 0.5 ms, 0.05 Hz) to induce lumbar SEP. The HNS (mechanic clamp) was applied sequentially to the tail, right hind paw, right forepaw, muzzle and left forepaw during sural stimulation. N wave amplitude decreases (-16.6 %) compared to control conditions when HNS was applied to all areas of stimulation. This effect was more intense for muzzle stimulation (-23.5 %). N wave duration also decreased by -23.6 %. HNS did not change neither the amplitude nor the duration of the P wave but dramatically increases the dispersion of these two parameters. The results of the present study strongly suggest that a HNS applied to different parts of the body is able to reduce the integrated electrical response of the SDH, suggesting that not only wide dynamic range neurons but many others in the SDH are modulated by the EPM.

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“…primary and secondary somatosensory cortex) would increase, which leads to better discriminative processing of nociceptive stimuli (Carlsson et al ., 2000, 2006). In contrast, in both humans and rats, when pain cannot be anticipated with certainty, there would be increased anxiety and hyperalgesia, along with greater physiological arousal (Oka et al ., 2010; Schaap et al ., 2013; Labrenz et al ., 2016). When pain is unpredictable, individuals have greater anxiety, which exacerbates the subjective perception of pain intensity as well as neuronal responses to constant pain stimulation (Ploghaus et al ., 2001).…”

Section: Introductionmentioning

confidence: 99%

Predictability modulates the anticipation and perception of pain in both self and others

Peng

Huang

Liu

et al. 2019

Social Cognitive and Affective Neuroscience

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Predictability has been suggested to modulate both the anticipation and perception of self-pain. Considering the overlapping neural circuits between self-pain and other-pain perceptions, the present study investigated how the predictability of forthcoming pain modulates the anticipation and perception of self-pain and other-pain. We used a balanced, within-participant experimental design in which a visual cue indicating the recipient, intensity and predictability of an upcoming painful electrical stimulation was presented before its delivery. Subjective ratings and electroencephalography activities to the anticipation and perception of self-pain and other-pain were recorded and compared between certain and uncertain conditions. Results showed that predictability affected the perception of self-pain and other-pain in a similar manner such that the differences in behavioral ratings and event-related potentials to high-intensity and low-intensity pain were significantly reduced when the intensity was uncertain. The strengths of predictability-induced modulation of self-pain and other-pain perceptions were positively correlated with each other. Furthermore, predictability also modulated the anticipation of both self-pain and other-pain such that pre-stimulus high-frequency α-oscillation power at sensorimotor electrodes contralateral to the stimulation side was maximally suppressed when anticipating certain high-intensity pain. These findings demonstrate that predictability-induced modulation on pain anticipation and perception was similarly applied to both self-pain and other-pain.

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Predictability of Painful Stimulation Modulates the Somatosensory-Evoked Potential in the Rat

Cited by 8 publications

References 37 publications

Brain-wide maps of Fos expression during fear learning and recall

Brain-wide maps of Fos expression during fear learning and recall

Noxious mechanical heterotopic stimulation induces inhibition of the spinal dorsal horn neuronal network: analysis of spinal somatosensory-evoked potentials

Predictability modulates the anticipation and perception of pain in both self and others

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