Predictability and other aspects of post-transplant diabetes mellitus in heart transplant recipients

An unexpectedly high prevalence of undiagnosed diabetes in patients awaiting lung transplantation

“…In the only study of heart transplant patients using the OGTT prior to transplantation, no new cases of diabetes were detected, but IGT was present in 55 of 141 (39%). 25 Newly diagnosed DM is also less common in renal transplant patients. Using OGTT, newly diagnosed pre-transplant DM and pre-diabetes were found, respectively, in 15 and 115 of 378 renal transplant patients without known DM.…”

Impact of Pre-Operative Diabetes Mellitus Upon Early and Late Survival After Heart Transplantation: A Possible Era Effect

“…4,5,8,9,11 An impaired oral glucose tolerance before heart transplantation was recently described as a suitable predictor of the development of post-transplant diabetes. 13 Thus, post-transplant diabetes is most likely steroid-induced in patients with pre-existing glucose intolerance. The cumulative incidence of post-transplant diabetes among patients in the aforementioned study was 19.6%, 83% of whom became manifest within 3 months post-transplant.…”

“…11 These results were supported by findings from a large multi-center cardiac transplant research database wherein diabetes mellitus was an independent predictor of death in the late posttransplant phase. 1 Predictors for developing diabetes mellitus after heart transplantation have been described, 12,13 but its relevance in terms of outcome, such as survival in relation to pre-operative diabetes, is currently unclear.…”

The Clinical Course and Outcomes of Post-Transplantation Diabetes Mellitus after Heart Transplantation

“…PTDM has been shown to be an independent risk factor of graft failure, cardiovascular disease, and death in kidney (3-5) and liver transplantation (6, 7). However, only a small number of studies have investigated the predisposing factors of PTDM in heart transplantation (HT) (8-11). Regarding its impact on the natural course and prognosis of HT, only two previous studies were published and showed no differences in the incidence of coronary vasculopathy and mortality after HT (10, 12).…”