Prediagnostic symptoms and signs of adult glioma: the patients’ view

Peeters, Marthe; Dirven, Linda; Koekkoek, Johan A F; Gortmaker, Ellen; Fritz, Lara; Vos, Maaike J.; Taphoorn, Martin J.B.

doi:10.1007/s11060-019-03373-y

Cited by 16 publications

(15 citation statements)

References 36 publications

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“…The prevalence of pre-treatment sleep disorders was 66.7% and higher than in patients with solid cancers such as breast cancer (42.3%), gynecological cancers (46.8%), head-andneck-cancers (42.7%), and prostate cancer (20.8%) (20)(21)(22)(23). Moreover, the prevalence in the current study was higher than in a study of patients with recurrent glial neoplasms (46.8%), in a study evaluating patients with glioma following surgical resection (33.7%), and in a study evaluating sleep problems during the year prior to the diagnosis of adult glioma (41%) (11,24,25). However, due to the different settings, it does not appear reasonable to compare these data to the results of our present study.…”

Section: Discussioncontrasting

confidence: 88%

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

Kopelke

Kjær

Tvilsted

et al. 2021

In Vivo

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Background/Aim: Many patients with malignant gliomas are scheduled for radiochemotherapy, which may cause emotional distress associated with sleep problems. This study aimed to determine the prevalence of such sleep problems in these patients and identify risk factors. Patients and Methods: Fifty-seven patients scheduled for radiochemotherapy for grade II-IV gliomas were retrospectively investigated for pre-treatment sleep problems. Fifteen characteristics were evaluated including temporal relation to age, gender, performance status, comorbidity, (family) history of malignancies, distress score, emotional problems, physical problems, practical problems, involved sites, glioma grade, upfront surgery, and corticosteroids. Results: Nineteen patients stated pre-treatment sleep problems (prevalence=66.7%). Significant associations with sleep problems were found for female gender (p=0.023), presence of emotional problems (p=0.006), and ≥4 physical problems (p<0.001). A trend was found for distress scores ≥5 (p=0.077). Conclusion: The prevalence of sleep problems was high. Risk factors were determined that can be used to identify patients who likely benefit from psychological support.According to the classification of the World Health Organization (WHO), the group of gliomas includes four grades (grades I to IV), of which grade IV tumors (glioblastoma multiforme) are the most aggressive lesions with a 5-year survival rate of about 5% (1-3).Neurosurgical resection should be performed whenever safely possible. In patients with grade III or IV gliomas, resection is generally followed by radiochemotherapy (4-6). This applies also to selected patients with grade II gliomas, mainly after incomplete resection. Assignment to a course of radiochemotherapy may cause significant distress for the patients who may be afraid particularly of the exposure to radiation and potential treatment-related adverse events (7-10). The distress may lead to sleep problems that can significantly impair the patients' quality of life and require psychological support already prior to the start of radiochemotherapy (11)(12)(13). Therefore, the present study investigated the prevalence and potential risk factors of pre-treatment sleep problems in patients with grade II to IV gliomas assigned to radiochemotherapy. These data can contribute to the identification of patients who would likely benefit from psychological support beginning already prior to their course of radiochemotherapy. Patients and MethodsIn this retrospective study, 57 patients scheduled for radiochemotherapy of WHO grade II-IV gliomas were investigated with respect to pre-treatment sleep problems. These patients had completed the National Comprehensive Cancer Network (NCCN) Distress Thermometer (14,15) between February 2019 and March 2021. The study was approved as a part of a larger project by the Ethics Committee of the University of Lübeck (reference 21-284). The technique to be used for the planned radiotherapy was volumetricmodulated arc therapy (VMAT). The preferred dose-frac...

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Section: Discussioncontrasting

confidence: 88%

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

Kopelke

Kjær

Tvilsted

et al. 2021

In Vivo

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“…The evolution of neurological symptoms and signs enables the estimation of the growth dynamics of gliomas: tumours that cause symptoms only weeks before diagnosis are usually fast growing whereas those that cause symptoms for years before being diagnosed are usually slow growing. In most individuals, the symptoms and signs reported the year before diagnosis are non-specific (for example, fatigue or headache) [9][10][11] . A discussion of the patient's history might reveal familial risk or rare exogenous risk factors (such as exposure to radiation) associated with the development of brain tumours.…”

Section: History and Clinical Examinationmentioning

confidence: 99%

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

et al. 2020

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In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy — Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.

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“…What other differences will arise for ship types such as bulk carriers, fishing vessels, tugboats, pleasure crafts, and cruise ships can be demonstrated by analyzing past accidents. Lastly, although many studies ( 31 – 41 ) in the literature based the research results on the opinions of a small expert group, as in this study, the results of this study can be extended with a larger expert group in future studies.…”

Section: Discussionmentioning

confidence: 93%

Fuzzy Multiple-Criteria Decision Making Based Evaluation of the Incident Analysis Forms Used in Internal Reporting Systems: A Case Study of Tanker Shipping Companies

Keçeci

2021

Transportation Research Record

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Under the International Safety Management (ISM) Code, shipping companies are required to build a Safety Management System and develop procedures that will regulate the incident analysis process. By these procedures, the shipping companies develop an incident analysis form and use it on all ships within their fleets. Although these forms serve a common purpose, their structure shows some differences between companies. Thus, time may be wasted when transferring the data or insufficient data may be obtained. This paper examines incident analysis forms used for tanker ships whose hazardous cargos make them of particular importance. The features of incident analysis forms used on tankers of a shipping company were specified, and the fuzzy analytic hierarchy process (FAHP) method presented their importance levels. Expert opinion was collected by a questionnaire. The results revealed that the highest priorities belong to the sections allocated for details about the ship and environmental conditions and root cause analysis technique. The least essential sub-criteria were related to the structure and variety of the forms. Based on the study results, which captured the current practice and the sector’s expectations, tanker shipping companies’ existing incident analysis forms could be revised. The revised documents would help to achieve complete information and prevent loss of time in information exchange between companies. Bringing a common approach to the analysis of incidents in tanker shipping would increase safety in the shipping industry.

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Prediagnostic symptoms and signs of adult glioma: the patients’ view

Cited by 16 publications

References 36 publications

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Fuzzy Multiple-Criteria Decision Making Based Evaluation of the Incident Analysis Forms Used in Internal Reporting Systems: A Case Study of Tanker Shipping Companies

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