Prediagnostic Serum Selenium in a Case-Control Study of Thyroid Cancer

Glattre, Eystein; Thomassen, Yngvar; Sø, Thoresen; Haldorsen, Tor; Lund‐Larsen, Per G.; Theodorsen, L.; Aaseth, Jan

doi:10.1093/ije/18.1.45

Cited by 134 publications

(54 citation statements)

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“…Also, lower selenium concentrations can be found in thy-roid tumor tissue (Köhrle, 1999a). In a large-scale Norwegian study, a significantly higher incidence of thyroid tumors correlated with prediagnostical low selenium levels (Glattre et al, 1989). The role of the individual selenoproteins in pathologically altered thyroid tissue is, however, as unclear as their contribution to auto-immune diseases and tumor development.…”

Section: Selenium and Thyroid Functionmentioning

confidence: 99%

Selenium in Biology: Facts and Medical Perspectives

Köhrl¹,

Brigelius‐Flohé²,

Böck³

et al. 2000

Biological Chemistry

245

143

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Several decades after the discovery of selenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21 st proteinogenic amino acid, selenocysteine, have been identified, partially characterized or cloned from several species. Many of these proteins are involved in redox reactions with selenocysteine acting as an essential component of the catalytic cycle. Enzyme activities have been assigned to the glutathione peroxidase family, to the thioredoxin reductases, which were recently identified as selenoproteins, to the iodothyronine deiodinases, which metabolize thyroid hormones, and to the selenophosphate synthetase 2, which is involved in selenoprotein biosynthesis. Prokaryotic selenoproteins catalyze redox reactions and formation of selenoethers in (stress-induced) metabolism and energy production of E. coli, of the clostridial cluster XI and of other prokaryotes. Apart from the specific and complex biosynthesis of selenocysteine, selenium also reversibly binds to proteins, is incorporated into selenomethionine in bacteria, yeast and higher plants, or posttranslationally modifies a catalytically essential cysteine residue of CO dehydrogenase. Expression of individual eukaryotic selenoproteins exhibits high tissue specificity, depends on selenium availability, in some cases is regulated by hormones, and if impaired contributes to several pathological conditions. Disturbance of selenoprotein expression or function is associated with deficiency syndromes (Keshan and Kashin-Beck disease), might contribute to tumorigenesis and atherosclerosis, is altered in several bacterial and viral infections, and leads to infertility in male rodents.

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Section: Selenium and Thyroid Functionmentioning

confidence: 99%

Selenium in Biology: Facts and Medical Perspectives

Köhrl¹,

Brigelius‐Flohé²,

Böck³

et al. 2000

Biological Chemistry

245

143

View full text Add to dashboard Cite

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“…In a case-control study of 43 cases and 129 matched controls in Norway, prediagnostic serum selenium levels were inversely associated with thyroid cancer; levels ≤1.25 and 1.26-1.64 μmol/l were associated with a 7.70-and 6.10-fold increased risk of thyroid cancer compared to levels ≥1.65 μmol/l (Glattre et al, 1989). This case-control study also showed, when considering the delay from blood sampling to diagnosis of the case, that the protective effect of high serum selenium concentrations was restricted to the seven-year period prior to the diagnosis of thyroid cancer, because the serum selenium concentration of cases tended to decrease, relatively to controls, when the delay from blood sampling to the diagnosis was shorter.…”

Section: Discussionmentioning

confidence: 99%

“…One in vitro study showed that selenium causes growth inhibition of thyroid cancer cells accompanied by cell-cycle arrest in the S and G2/M phases (Kato et al, 2010). In addition, a small case-control study of 43 thyroid cancer cases showed a significant increased risk for low compared to high prediagnostic serum selenium concentrations (Glattre et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was 0.76 μg/g. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands (M=0.87 μg/g) and in the Tuamotu-Gambier Archipelago (M=0.86 μg/g). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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“…In 1989 we published our second study of the same 43 thyroid cancer cases and their 128 controls, this time with regard to the trace elements selenium and copper (7). In agreement with our hypothesis the cases were significantly lower in serum selenium than controls, and the odds ratio of thyroid cancer increased from 1 for s-levels ≥ 1.65 µmol/l, to 6.1 for s-levels 1.26-1.64 µmol/l, to 7.7 for s-levels ≤ 1.25 µmol/l.…”

Section: Janus Bank Studiesmentioning

confidence: 99%

“…The 1990-study of selenium concentrations in the human thyroid gland, showing that the gland is the most selenium-rich tissue in the human body (8), together with this case-control study have contributed significantly to the present interest in the significance and function of selenium in thyroid gland pathophysiology. Papers (7,8) are not infrequently referred to.…”

Section: Janus Bank Studiesmentioning

confidence: 99%

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

Glattre¹

2011

Nor J Epidemiol

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The Norwegian Thyroid Cancer Project was established in 1985. Its crew has consisted of an interdisciplinary group of scientists, and its secretariat has been part of the Cancer Registry of Norway since day 1. The aim has been to describe the occurrence of thyroid cancer in Norway, investigate etiological aspects and publish results. Focus has been on the papillary carcinoma of the thyroid, the most incident type of thyroid neoplasia in Norway. Important results of the Project are briefly mentioned. Some forty publications have been produced, mostly epidemiological analyses, but also some experimental studies. The results of the Project and of others have led to the acknowledgement that thyroid carcinogenesis is a complexity-phenomenon partly inaccessible to common scientific procedure. NORSK SAMMENDRAGCancer thyreoidea prosjektet kom igang i 1985. De forskere som har arbeidet innenfor prosjektet, har hatt forskjellig faglig bakgrunn. Prosjektsekretariatet har ligget i Kreftregisteret helt fra starten av. Målsetningen har hele tiden vaert å beskrive opptredenen av skjoldkjertelkreft i Norge samt gjøre etiologiske undersøkelser. Fokus har vaert på det papillaere carcinom som er det hyppigste her til lands. En del viktige forskningsresultater blir kort omtalt. Det er produsert ca. 40 publikasjoner i regi av Prosjektet, den overveiende del er epidemiologiske analyser, i tillegg noen dyreeksperimenter. De samlede erfaringene har ført til den erkjennelse at thyreoidea-karsinogenesen er et kompleksfenomen som bare delvis er tilgjengelig for vitenskapelig forskning.

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Prediagnostic Serum Selenium in a Case-Control Study of Thyroid Cancer

Cited by 134 publications

References 0 publications

Selenium in Biology: Facts and Medical Perspectives

Selenium in Biology: Facts and Medical Perspectives

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

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