Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Hughes, David J.; Duarte‐Salles, Talita; Hybsier, Sandra; Trichopoulou, Antonia; Stępień, Magdalena; Aleksandrova, Krasimira; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Affret, Aurélie; Fagherazzi, Guy; Boutron-Ruault, Marie Christine; Katzke, Verena; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Λάγιου, Παγώνα; Peppa, Eleni; Palli, Domenico; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, H. B.; Peeters, Petra H.M.; Engeset, Dagrun; Weiderpass, Elisabete; Lasheras, Cristina; Agudo, Antonio; Sánchez, María José; Navarro, Carmen; Ardanáz, Eva; Dorronsoro, Miren; Hemmingsson, Oskar; Wareham, Nicholas J.; Khaw, Kay Tee; Bradbury, Kathryn E.; Cross, Amanda J.; Gunter, Marc J.; Riboli, Elio; Romieu, Isabelle; Schomburg, Lutz; Jenab, Mazda

doi:10.3945/ajcn.116.131672

Cited by 71 publications

(46 citation statements)

References 52 publications

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“…With the search strategy stated before, 9 relevant records were included in our meta-analysis and data were extracted (Figure 1) [11, 12, 16, 17, 19–21, 23, 24]. Table 1 summarized the characteristics of the 9 enrolled studies.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Zhang

Bi²,

Liu

et al. 2016

Oncotarget

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Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method. Heterogeneity was assessed by using the I2 index. Publication bias was evaluated by Begg's Test analysis. Pooled analysis indicated that patients with HCC had lower Se levels than the healthy controls [standardized mean difference (SMD)= −1.08, 95% confidence intercal (CI) = (−0.136, −0.08), P < 0.001]. Further subgroup analysis showed this effect to be independent of the study design, race or sample collection. In conclusion, this meta-analysis suggested an inverse correlation between Se level and the risk of HCC in humans patients.

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Section: Resultsmentioning

confidence: 99%

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Zhang

Bi²,

Liu

et al. 2016

Oncotarget

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“…[11][12][13][14] Dietary micronutrients such as vitamin A, C and E, Se, Fe, Zn, Mn and Cu are necessary to regulate the reactions that release OFR and modulate the host susceptibility or resistance to infectious pathogens, thus may reduce the liver cancer risk. 7,[15][16][17][18] In our previous study, we have found that high intake of vitamin E was related to lower risk of liver cancer in middleaged or older people from China. 16 However, there were no prospective cohort studies evaluating the relationship between dietary trace elements and liver cancer risk.…”

Section: Introductionmentioning

confidence: 96%

Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Yang

et al. 2016

Intl Journal of Cancer

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Dietary factors have been hypothesized to affect the risk of liver cancer via various mechanisms, but the influence has not been well studied and the evidence is conflicting. We investigated associations of dietary trace element intake, assessed through a validated food frequency questionnaire, with risk of liver cancer in two prospective cohort studies of 132,765 women (1997–2013) and men (2002–2013) in Shanghai, China. The associations were first evaluated in cohort studies and further assessed in a case-control study nested within these cohorts adjusting for hepatitis B virus infection. For cohort analyses, Cox proportional hazard models were used to estimate hazard ratios and 95% confidence intervals. For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. After a median follow-up time of 15.2 years for the Shanghai Women’s Health Study and 9.3 years for the Shanghai Men’s Health Study, 192 women and 344 men developed liver cancer. Dietary intake of manganese was inversely associated with liver cancer risk (highest vs. lowest quintile, HR = 0.51, 95% CI: 0.35–0.73; ptrend = 0.001). Further adjustment for hepatitis B virus infection in the nested case-control study yielded a similar result (highest vs. lowest quintile, OR = 0.38, 95% CI: 0.21–0.69; ptrend < 0.001). No significant associations were found between dietary intake of selenium, iron, zinc, copper and liver cancer risk. The results suggest that higher intake of manganese may be associated with a lower risk of liver cancer in China.

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“…stomach-and hepatocellular cancer as well as risk of advanced prostate cancer, although a protective effect of Se-supplementation has been questioned for those cancers. 2,5,[8][9][10][11] In the 1990s several studies were performed regarding Se and breast cancer risk but they showed inconclusive results, with some reporting an inverse relationship and some not finding any association. [12][13][14][15][16][17][18] A review of these studies in 2007 showed no overall association with the risk of breast cancer.…”

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confidence: 99%

Selenium and breast cancer risk: A prospective nested case–control study on serum selenium levels, smoking habits and overweight

Sandsveden

Manjer

2017

Intl Journal of Cancer

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Previous research has not been conclusive regarding the association between selenium (Se) and breast cancer. This study was conducted to clarify if there is an association between prediagnostic serum Se levels and breast cancer risk. A population based cohort, the Malmö Diet and Cancer Study, was used and linked with the Swedish cancer registry up to 31 December 2013. Our study included 1,186 women with breast cancer and an equal number of controls. Selenium levels were analysed from stored serum samples. The included individuals were divided into quartiles based on Se value and we compared breast cancer cases with controls using logistic regression yielding odds ratios (OR) with 95% confidence intervals. Serum Se was also analysed as a continuous variable regarding breast cancer risk. The analyses were adjusted for established risk factors and stratified on smoking status and body mass index (BMI). When comparing the highest Se quartile with the lowest, the adjusted OR for breast cancer was 0.98 (0.75-1.26). With selenium as a continuous variable the adjusted OR was 1.00 (1.00-1.01) per 10 ng/ml. When comparing the highest with the lowest Se quartile in women with BMI > 25 kg/m the adjusted OR was 0.77 (0.53-1.14). We conclude that it is unlikely that prediagnostic serum selenium is overall associated with breast cancer risk and no modifying effect from BMI or smoking was seen.

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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Abstract: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.

Cited by 71 publications

References 52 publications

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Selenium and breast cancer risk: A prospective nested case–control study on serum selenium levels, smoking habits and overweight

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