Prediagnostic presentations of Parkinson's disease in primary care: a case-control study

Schrag, Anette; Horsfall, Laura; Walters, Kate; Noyce, Alastair J.; Petersen, Irene

doi:10.1016/s1474-4422(14)70287-x

Cited by 503 publications

(501 citation statements)

References 36 publications

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“…64 Based on the Newcastle-Ottawa scale, two-thirds of the observational studies examining the association between alcohol and PD had low quality ratings. Moreover the finding that ibuprofen use, but not use of aspirin or other 78,79 This is why the identification of a biomarker could be a breakthrough to help slow the progression of PD, by recognizing it at an earlier, preclinical even, stage. However none of the meta-analyses on biomarkers showed unequivocal evidence for association with PD.…”

mentioning

confidence: 99%

Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

Bellou

Belbasis

Tzoulaki

et al. 2016

Parkinsonism & Related Disorders

307

259

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mentioning

confidence: 99%

Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

Bellou

Belbasis

Tzoulaki

et al. 2016

Parkinsonism & Related Disorders

307

259

View full text Add to dashboard Cite

“…In the prodromal stage, the most common NMS manifestations are olfactory impairment and raid eye movement behavior disorder while other features such as constipation, somnolence, apathy, fatigue may also be present [9]. The development of many of these symptoms is consistent with the Braak pathology staging in which Lewy bodies first develop in the dorsal motor nucleus of the vagus nerve, the olfactory bulb, enteric nervous system and the submandibular gland, and then later spread to the substantia nigra, areas of the midbrain and basal forebrain, and finally reach areas of the neocortex [10].…”

Section: Animal Models Of Disease Pathologymentioning

confidence: 99%

Unmet needs in Parkinson's disease: New horizons in a changing landscape

Bhidayasiri

Laar

2016

Parkinsonism & Related Disorders

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a b s t r a c tThe success of levodopa and other classes of drugs have meant that most people with Parkinson's disease enjoy a good quality of life for many years. However, despite the availability of several drugs and formulations that can be used as monotherapy and in combination, there are a number of disease features that the current therapies are unable to address. The disease continues to progress despite treatment, patients suffer from a myriad of motor and non-motor symptoms, and a neuroprotective therapy is urgently required. To move forward with medical and surgical management, it is important to consider new insights that recent research offers and in this review we examine how a better understanding of the disease pathology and progression might improve and enrich our daily clinical practice. It is also timely to consider the service provision changes that will increasingly be needed to effectively manage the needs of the aging population.

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“…Casecontrol studies are also less efficient when the exposure is rare as it takes a larger sample size to collect enough patients with exposure (12). More studies employing case-control published can be seen in the Lancet (13,14), the New England Journal of Medicine (15,16), Journal of American Medical Association (17), and Anesthesiology (18).…”

Section: Case-control Studiesmentioning

confidence: 99%

Observational Studies in Anesthesiology

Yu¹

2016

J Anesth Perioper Med

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Aim of review:Through this review of observational study designs, we aim to advocate the use of non-interventional studies for clinical researches in anesthesiology. Method: We discussed the statistical considerations in selecting study design and the analysis. The major consideration is to reduce the bias and improvement efficiency. Reduction of bias through design (e.g.: randomization, matching etc.) is more preferable. However, a more objective design such as the randomized clinical trial is often not feasible. In this case, observational study designs accompanied with more advanced and complete statistical analysis can reduce the bias and improve efficiency. The cross-sectional, case-control, and cohort study designs are discussed with the advantages and limitations. Recent findings: With the rapid development of clinical researches in anesthesiology in past 15 years, observational studies are still yet to be understood and utilized. Summary: Through this review, we expect to raise more attention in the use of observational studies in clinical researches in the area of anesthesiology.

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Prediagnostic presentations of Parkinson's disease in primary care: a case-control study

Abstract: Parkinson's UK.

Cited by 503 publications

References 36 publications

Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

Unmet needs in Parkinson's disease: New horizons in a changing landscape

Observational Studies in Anesthesiology

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