Prediagnostic Inflammation and Pancreatic Cancer Survival

Yuan, Chen; Morales-Oyarvide, Vicente; Khalaf, Natalia; Perez, Kimberly; Tabung, Fred K.; Ho, Gloria Y.F.; Kooperberg, Charles; Shadyab, Aladdin H.; Qi, Lihong; Kraft, Peter; Sesso, Howard D.; Giovannucci, Edward; Manson, Jo Ann E.; Stampfer, Meir J.; Ng, Kimmie; Fuchs, Charles S.; Wolpin, Brian M.; Babić, Ana

doi:10.1093/jnci/djab040

Cited by 10 publications

(6 citation statements)

References 44 publications

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“…We selected CRP as a marker of chronic inflammation in the human body to explore its mediating role in obesity-induced PC. After reviewing a large body of data, we are concerned that chronic inflammation is an important risk factor for PC ( 28 ). However, in recent years, the research direction has begun to shift to the value of inflammatory markers in the human body on the survival and prognosis of PC.…”

Section: Discussionmentioning

confidence: 99%

Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

Jin²,

Xia³

et al. 2023

Front. Oncol.

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AimTo explore whether C-reactive protein (CRP) mediates the risk of body mass index (BMI) in pancreatic cancer (PC) and calculate the mediate proportion of CRP in this possible mechanism.MethodsBased on two-sample Mendelian randomization (TSMR), a two-step Mendelian randomization (TM) model was conducted to determine whether CRP was a mediator of the causal relationship between BMI and PC. The multivariable Mendelian randomization (MVMR) study was designed for mediating analysis and to calculate the mediating proportion mediated by CRP.ResultsBMI has a positive causal relationship with PC (n = 393 SNPs, OR = 1.484, 95% CI: 1.021–2.157, p< 0.05). BMI has a positive causal relationship with CRP (n = 179 SNPs, OR = 1.393, 95% CI: 1.320–1.469, p< 0.05). CRP has a positive causal relationship with PC (n = 54 SNPs, OR = 1.348, 95% CI: 1.004–1.809, p< 0.05). After adjusting CRP, BMI has no causal relationship with PC (n = 334 SNPs, OR = 1.341, 95% CI: 0.884–2.037, p< 0.05). After adjusting BMI, there was still a positive causal relationship between CRP and PC (n = 334 SNPs, OR = 1.441, 95% CI: 1.064–1.950, p< 0.05). The mediating effect of CRP was 29%.ConclusionsIn clinical practice, while actively advocating for weight loss among obese patients, we should focus on chronic inflammation levels in obese patients as well. In addition, anti-inflammatory dietary patterns and appropriate physical activity are important in preventing PC.

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Section: Discussionmentioning

confidence: 99%

Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

Jin²,

Xia³

et al. 2023

Front. Oncol.

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“…Cancer-related in ammation is a critical component of tumor progression: various growth factors, cytokines, and chemokines are released by in ammatory cells (21). Several studies have revealed that relevant biomarkers can predict the prognosis of patients with cancer, such as C-reactive protein, interleukin-6, and tumor necrosis factor-α receptor 2 in pancreatic cancer (22), SII index in bladder cancer (23), colorectal cancer (24), and prostate cancer (25). Nutrition-related indexes were also widely reported as cancer prognostic predictors.…”

Section: Discussionmentioning

confidence: 99%

An inflammatory–nutritional score for predicting survival benefit after curative resection for Perihilar cholangiocarcinoma

Nie,

Peng,

Wen

et al. 2023

Preprint

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Background Perihilar cholangiocarcinoma (pCCA) is the most common malignancy of the biliary tree. Resection is the only potentially curative treatment for pCCA. Systemic inflammation and nutrition status are sources of important prognostic factors for patients with pCCA. In this study, a risk score, named “neutrophil-albumin-bilirubin (NAB)”, was developed and validated based on inflammation and nutrition status biomarkers for patients with pCCA. Methods A total of 161 patients who underwent surgical resection between December 2008 to April 2016 were included in this retrospective cohort study (118 in the training set and 43 in the validation set). NAB were developed from preoperative blood biomarkers via Least absolute shrinkage and selection operator (LASSO) and Cox regression in training and validation cohorts. Time-dependent receiver operating characteristic curves and Kaplan–Meier analysis were used to verify the prognostic prediction value of the NAB score for resectable pCCA. Nomograms were also established to validate the clinical use of this model for overall survival and recurrence-free survival evaluation. Results Based on albumin–bilirubin (ALBI) grade and neutrophil biomarkers, NAB classified patients into high-risk and low-risk groups when patients with high-risk scores had shorter OS (p < 0.05) and RFS (p < 0.05) than patients with low-risk scores. The relationship between NAB and lymph node metastasis was also claimed(p = 0.004). Furthermore, the high NAB score was a significant independent prognostic factor of OS and RFS in both the training (p = 0.001) and validation (p = 0.037) cohorts, respectively. A NAB-nomogram combined with other independent prognostic factors, like ASA grade, lymph node metastases, perineural invasion and so on, was constructed for individualized prognostic prediction. Conclusion NAB could serve as a robust prognostic biomarker and be helpful for surgical decision-making in patients with pCCA.

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“…Such chronic low-grade inflammation complicated with WAT has the potential to form a closed loop above the mechanism that leads to an inflammatory cycle, maintaining or amplifying the inflammation of AT. Chronic inflammation with a high level of CRP or TNF-a receptor 2 prove to initiate the original of PC and make progression to the metastasis, prediagnostic proficiency of inflammatory biomarkers provably correlates negatively with pancreatic cancer survival (116). This meta-inflammation caused by obesity or WAT has been accepted to be related to the pancreas and its inflammation.…”

Section: Wat Related Chronic Low-grade Inflammationmentioning

confidence: 99%

The Role of Adipokines in Pancreatic Cancer

Wang

Ding

et al. 2022

Front. Oncol.

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In modern society, inappropriate diets and other lifestyle habits have made obesity an increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive malignant tumor, is known as a silent assassin and is the seventh leading cause of cancer death worldwide, pushing modern medicine beyond help. Adipokines are coming into notice because of the role of the intermediate regulatory junctions between obesity and malignancy. This review summarizes the current evidence for the relationship between highly concerning adipokines and the pathogenesis of PC. Not only are classical adipokines such as leptin and adiponectin included, but they also cover the recognized chemerin and osteopontin. Through a summary of the biological functions of these adipokines as well as their receptors, it was discovered that in addition to their basic function of stimulating the biological activity of tumors, more studies confirm that adipokines intervene in the progression of PC from the viewpoint of tumor metabolism, immune escape, and reprogramming of the tumor microenvironment (TME). Besides endocrine function, the impact of white adipose tissue (WAT)-induced chronic inflammation on PC is briefly discussed. Furthermore, the potential implication of the acknowledged endocrine behavior of brown adipose tissue (BAT) in relation to carcinogenesis is also explored. No matter the broad spectrum of obesity and the poor prognosis of PC, supplemental research is needed to unravel the detailed network of adipokines associated with PC. Exploiting profound therapeutic strategies that target adipokines and their receptors may go some way to improving the current worrying prognosis of PC patients.

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Prediagnostic Inflammation and Pancreatic Cancer Survival

Cited by 10 publications

References 44 publications

Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

An inflammatory–nutritional score for predicting survival benefit after curative resection for Perihilar cholangiocarcinoma

The Role of Adipokines in Pancreatic Cancer

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