Prediabetes is associated with genetic variations in the gene encoding the Kir6.2 subunit of the pancreatic ATP‐sensitive potassium channel (KCNJ11): A case‐control study in a Han Chinese youth population

Abstract

The results confirm that the common E23K polymorphism of KCNJ11 carries a higher susceptibility to the development of prediabetes in the Chinese Han population. The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth.

Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels

“…Regarding genetic aspects, the SNP rs5215_GG for the Kir6.2 subunit of KATP channels was statistically associated with the absence of DM. Moreover, in our population, SNP rs5219 did not present any significant correlation with diabetes mellitus, different to observations made by some authors [ 83 , 92 , 93 , 95 ]. Interestingly, in nondiabetic patients, the presence of rs5215_GG was more frequently observed in patients with normal coronary arteries, although they present other cardiovascular risk factors such as hypertension and dyslipidemia, compared with patients with CAD and with patients with microvascular disease.…”

“…K-ATP channels seem to also have a main role in the simultaneous regulation of α cell activity. As regards α cells, K-ATP closure is paradoxically related to cell hyperpolarization and glucagon secretion inhibition [ 82 , 83 ]. K-ATP channel function is strictly associated with insulin and glucagon secretion and, therefore, with blood glucose levels.…”

“…In this syndrome, the increased K-ATP channel function determines reduced β cell depolarization, which causes lower insulin secretion in response to the increase of glucose blood levels [ 87 , 88 , 89 ]. The EK and KK genotypes of the E23K allele, also named rs5219, of KCNJ11 reduce β cell function and represent an independent risk factor for the onset of the prediabetes in youth [ 83 ], a condition defined by the presence of lower blood glucose fasting levels than the diabetes mellitus threshold, but higher than normal ones [ 90 , 91 ]. Furthermore, the rs5219 polymorphism only predisposes young females to T2DM [ 83 ].…”

“…The EK and KK genotypes of the E23K allele, also named rs5219, of KCNJ11 reduce β cell function and represent an independent risk factor for the onset of the prediabetes in youth [ 83 ], a condition defined by the presence of lower blood glucose fasting levels than the diabetes mellitus threshold, but higher than normal ones [ 90 , 91 ]. Furthermore, the rs5219 polymorphism only predisposes young females to T2DM [ 83 ]. A study by Rastegari et al underlined the association between the KK homozygous genotype of the E23K polymorphism of the KCNJ11 gene and T2DM in adults [ 92 ].…”

ATP-sensitive potassium channels gene polymorphism rs1799858 affects the risk of macro-/micro-vascular arteriosclerotic event in patients with increased low-density lipoprotein cholesterol levels

“…Importantly, the KATP gene exhibits characteristics with high level of genetic polymorphism. KATP polymorphisms not only associated with dyslipidemia (e.g., higher levels of triglyceride (TIRG), total cholesterol (TC) and LDL-C as well as lower HDL-C) [17][18][19], essential hypertension (EH) [20] and ASCVD (e.g., MI and stroke) [21,22] but also exhibited geographical and ethnic diversity (e.g., Africans, Europeans, East Asians). However, the relationship of KATP single nucleotide polymorphisms (SNPs) with increased LDL-C levels and its related macro-/micro-vascular arteriosclerotic events in China is rarely reported.…”