Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Melsom, Toralf; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Jenssen, Trond; Mathisen, Ulla Dorte; Wilsgaard, Tom; Eriksen, Bjørn Odvar

doi:10.1053/j.ajkd.2015.10.025

Cited by 76 publications

(91 citation statements)

References 39 publications

(47 reference statements)

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“…Researchers discovered that fasting glucose levels consistent with prediabetes are independent risk factors for hyperfiltration in the kidneys and the presence of albumin in the urine which are all indicators of kidney disease. They also show that the pathological process of kidney injury caused by elevated blood glucose levels starts in prediabetes ,well before the onset of diabetes [7]. There are many causes of kidney failure which include high blood pressure, glomerulonephritis, urologic diseases, or cystic disease.…”

Section: Introductionmentioning

confidence: 97%

“…The authors conclude that prediabetes is increasing in prevalence and that demographic subgroups may benefit from targeted diabetes prevention efforts. Research study suggests that high levels of glucose could be affecting kidneys even prior to diabetes diagnoses [7]. Kidney failure is a serious condition when kidneys fail to eliminate the body's waste and is the final stage of chronic kidney failure.…”

Section: Introductionmentioning

confidence: 99%

“…There are many causes of kidney failure which include high blood pressure, glomerulonephritis, urologic diseases, or cystic disease. Among those causes, diabetes is the most common cause of kidney failure accounting for almost 44% of new patient cases, Even with tight controls over blood glucose, patients with diabetes can still progress to kidney failure [7]. However, recent research shows that for the kidneys problems may begin to occur in prediabetic stage, long before a patient is actually diagnosed with diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…However, recent research shows that for the kidneys problems may begin to occur in prediabetic stage, long before a patient is actually diagnosed with diabetes. The study conducted at the university hospital of North Norway in Toronto, found that evidence of kidney damage that is typically associated with diabetes actually starts when blood sugar levels are consistent with prediabetes [7]. Screening for albuminuria and measurement of serum creatinine, urea and Electrolytes are currently recommended by the American Diabetes Association for the diagnoses of either diabetes or prediabetes and annually thereafter (standard of medical care in diabetes,2009).…”

Section: Introductionmentioning

confidence: 99%

“…For, et al [11] from the Framingham Heart study observed a stronger association between other cardiovascular risk factors and CKD observed in patients with prediabetes is due to macrovascular disease, especially hypertension and not in microvascular disease. Recent studies also showed that prediabetes is the leading cause of kidney failure accounting for 44% of new cases of kidney failure [7]. Some data indicated that lifestyle interventions for prediabetes can return individuals for normoglyceamia Perreault, et al [12] and Schellenberg and Dryden [13].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Egbe¹,

Ozomma²,

Meludu³

et al. 2017

Journal of Diseases

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Article HistoryThis study was designed to investigate the prevalence of prediabetes and the associated risk of kidney disease in Nnewi, Nigeria. A total of 277 apparently healthy subjects (73males and 204 females) who were willing to participate were recruited. Anthropometric indices and blood pressure were measured using standard methods while the demographic data and dietary pattern of subjects were obtained using a wellstructured questionnaire. 5mls of blood was collected from eligible subjects (20 prediabetes and 20 non prediabetes ) and dispensed in fluoride oxalate and plain containers for glucose, creatinine (Cr), Urea(Ur), Na+, K+, Cl-, and HCO3-estimation respectively using standard methods. The result showed a prevalence of 7.2% prediabetes in the population. BMI was significantly higher in prediabetes than the control groups (39.4±5.8 vs 29±4.4kg/m2; P>0.05). Again, significant increases in the prediabetic values of FBG (117.54±16.84 vs 83±16.84mg/dl; P>0.05) than the control group were observed. The SBP (128± 11.26 vs 120±2.2mmHg; P>0.05) and DBP (92±4.43 vs 60±5.3mmHg; P>0.05) was also higher in prediabetic groups. Interestingly, result showed no significant difference between the renal parameters in prediabetes and non prediabetes (p>0.05). The study therefore, suggests that the major determinant for predabetes in the study population may be hypertension and obesity whereas kidney function was not impaired.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Egbe¹,

Ozomma²,

Meludu³

et al. 2017

Journal of Diseases

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Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals

et al. 2020

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IMPORTANCE Glomerular hyperfiltration is associated with increased risk of cardiovascular disease in high-risk conditions, but its significance in low-risk individuals is uncertain. OBJECTIVE To determine whether glomerular hyperfiltration is associated with increased cardiovascular risk in healthy individuals. DESIGN, SETTING, AND PARTICIPANTS This was a prospective population-based cohort study, for which enrollment took place from August 2009 to October 2010, with follow-up available through March 31, 2016. Analysis of the data took place in October 2019. The cohort was composed of 9515 healthy individuals, defined as individuals without hypertension, diabetes, cardiovascular disease, estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m 2 , or statin and/or aspirin use, identified among 20 004 patients aged 40 to 69 years with health information accessed through the CARTaGENE research platform. EXPOSURES Individuals with glomerular hyperfiltration (eGFR >95th percentile after stratification for sex and age) were compared with individuals with normal filtration rate (eGFR 25th-75th percentiles). MAIN OUTCOMES AND MEASURES Adverse cardiovascular events were defined as a composite of cardiovascular mortality, myocardial infarction, unstable angina, heart failure, stroke, and transient ischemic attack. Risk of adverse cardiovascular events was assessed using Cox and fractional polynomial regressions and propensity score matching. RESULTS From the 20 004 CARTaGENE participants, 9515 healthy participants (4050 [42.6%] male; median [interquartile range] age, 50.4 [45.9-55.6] years) were identified. Among these, 473 had glomerular hyperfiltration (median [interquartile range] eGFR, 112 [107-115] mL/min/1.73 m 2) and 4761 had a normal filtration rate (median [interquartile range] eGFR, 92 [87-97] mL/min/1.73 m 2). Compared with the normal filtration rate, glomerular hyperfiltration was associated with an increased cardiovascular risk (hazard ratio, 1.88; 95% CI, 1.30-2.74; P = .001). Findings were similar with propensity score matching. The fractional polynomial regression showed that only the highest eGFR percentiles were associated with increased cardiovascular risk. The cardiovascular risk of individuals with glomerular hyperfiltration was similar to that of the 597 participants with an eGFR between 45 and 60 mL/min/1.73 m 2 (hazard ratio, 0.90; 95% CI, 0.56-1.42; P = .64). CONCLUSIONS AND RELEVANCE These findings suggest that glomerular hyperfiltration is independently associated with increased cardiovascular risk in middle-aged healthy individuals. This risk profile appears to be similar to stage 3a chronic kidney disease.

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Renal Disease in Obesity, Metabolic Syndrome and Diabesity

Navarro-Díaz

Rodríguez-Rodríguez

2018

Diabetic Nephropathy

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Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Cited by 76 publications

References 39 publications

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals

Renal Disease in Obesity, Metabolic Syndrome and Diabesity

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