Prediabetes and gastrointestinal (GI) symptoms; a cross-sectional study

Ghadiri‐Anari, Akram; Gholami, Somayeh; Zolfaghari, Fariba; Namiranian, Nasim

doi:10.1016/j.dsx.2018.12.005

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…However, anti-diabetic drugs are known to have GI tolerability issues (28), which may be a confounding factor in our analyses. Although this is an important limitation, a similar study in pre-diabetic patients also reported an increase in GI symptoms (24), suggesting that DM causes GI symptoms even without drug use and before the definite development of the disease.…”

Section: Discussionmentioning

confidence: 87%

“…These limitations may be circumvented with specific study designs and conduct of studies involving strict limitations in patient inclusion. For instance, in a study by Ghadiri-Anari and colleagues (24), in which pre-diabetic patients were compared with healthy controls, the frequency of heartburn, nausea, bloating, early satiety, gas passage, and constipation were found to be significantly higher among pre-diabetics. This study design completely eliminates the possible effects of medications such as metformin on the frequency of GI symptoms; therefore enabling a much better comparison.…”

Section: Discussionmentioning

confidence: 98%

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Increased gastrointestinal symptom frequency in diabetes mellitus even with good glycemic control

Kalkan

Karatay

Akbal

2020

Journal of Health Sciences and Medicine

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Amaç: Gastrointestinal problemlerin, diabetes mellitus (DM) olan hastalarda, genel popülasyona göre daha sık olduğu ve yaşam kalitesinde azalmalya neden olduğu bildirilmektedir. Çalışmalar, glisemik kontrol ve hastalık süresi gibi parametrelerin DM'deki üst gastrointestinal semptomlardan sorumlu olduklarını ileri sürmelerine rağmen, bazı çalışmaların da hiçbir ilişki olmadığını bildirdiği gerçeği göz önüne alındığında doğrudan bir ilişki olduğunu gösteren çok az kanıt vardır. Bu çatışmalar, hasta popülasyonlarının standart olmamasından, değerlendirme yöntemlerinden ve diğer nedenlerden kaynaklanabilir. Amacımız yakın zamanda tanı almış DM hastalarında ve sağlıklı kontrollerde gastrointestinal semptomlarının sıklığını ve gastrointestinal semptomlar ile ilişkili yaşam kalitesini belirlemek ve karşılaştırmak, bu faktörlerin en aza indirgenmesini değerlendirmektir. Gereç ve yöntem: Çalışmaya DM tanısı konmuş toplam 59 hasta, 92 yaş ve cinsiyet uyumlu kontrol grubu dahil edildi. Demografik özellikler, kronik hastalıklar, GI semptomları (8-MGSI skoru ile ölçülen) ve irritabl barsak sendromu yaşam kalitesi(IBS-QOL) skorları değerlendirildi. IBS-QOL'ü bağımsız olarak etkileyen faktörleri belirlemek için doğrusal regresyon analizi yapıldı. Bulgular: Hasta ve kontrol grubu kronik hastalıklar dışındaki tüm özellikler açısından benzerdi. DM'li hastalarda 8-MGSI ve IBS-QOL skorları anlamlı olarak daha kötüydü. Regresyon analizleri İBS, DM ve dispepsinin IBS-QOL skorlarını etkileyen bağımsız faktörler olduğunu gösterdi. Sonuç: Çalışmamızın sonuçları, DM'nin gastrointestinal semptomlar üzerindeki etkisinin hastalık süresinin veya glisemik kontrolden etkilemediğini göstermektedir; DM'nin varlığı, henüz bilinmeyen mekanizmalar yoluyla gastrointestinal sistem üzerinde olumsuz etkilere sahiptir. Bu mekanizmaların açıklaması için hasta dahil etme kriterleri daha kesin olarak belirlenmiş deneysel çalışmalara ihtiyaç vardır

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Increased gastrointestinal symptom frequency in diabetes mellitus even with good glycemic control

Kalkan

Karatay

Akbal

2020

Journal of Health Sciences and Medicine

View full text Add to dashboard Cite

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“… 22 If constipation is not diagnosed and treated effectively and on time, it would seriously affect the quality of life of patients with diabetes, aggravate their bad mood, increase insulin resistance, affect the stability of blood sugar of patients with diabetes, and also result in cardiovascular and cerebrovascular accidents, intestinal rupture and perforation, sudden death, and other serious complications. 23 Therefore, an urgent problem to be solved in the diagnosis and treatment of patients with diabetes is to keep the defecation unobstructed.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Risk Nomogram Model for Predicting Constipation in Patients with Type 2 Diabetes Mellitus

Yuan¹,

Zhang²,

Peng³

et al. 2023

DMSO

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Purpose Constipation is a common complication of diabetic patients, which has a negative impact on their own health. This study aims to establish and internally validate the risk nomogram of constipation in patients with type 2 diabetes mellitus (T2DM) and to test its predictive ability. Patients and Methods This retrospective study included 746 patients with T2DM at two medical centers. Among the 746 patients with T2DM, 382 and 163 patients in the Beilun branch of the First Affiliated Hospital of Zhejiang University were enrolled in the training cohort and the validation cohort, respectively. A total of 201 patients in the First Affiliated Hospital of Nanchang University were enrolled in external validation cohorts. The nomogram was established by optimizing the predictive factors through univariate and multivariable logistic regression analysis. The prediction performance of the nomogram was measured by the area under the receiver operating characteristic curve (AUROC), the calibration curve, and the decision curve analysis (DCA). Furthermore, its applicability was internally and independently validated. Results Among the 16 clinicopathological features, five variables were selected to develop the prediction nomogram, including age, glycated hemoglobin (HbA1c), calcium, anxiety, and regular exercise. The nomogram revealed good discrimination with an area under the receiver operating characteristic curve (AUROC) of 0.908 (95% CI = 0.865–0.950) in the training cohort, and 0.867 (95% CI = 0.790–0.944) and 0.816 (95% CI = 0.751–0.881) in the internal and external validation cohorts, respectively. The calibration curve presented a good agreement between the prediction by the nomogram and the actual observation. The DCA revealed that the nomogram had a high clinical application value. Conclusion In this study, the nomogram for pretreatment risk management of constipation in patients with T2DM was developed which could help in making timely personalized clinical decisions for different risk populations.

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Risk factors for prediabetes in community‐dwelling adults: A generalized estimating equation logistic regression approach with natural language processing insights

Kim,

Jeon,

Lee

et al. 2024

Research in Nursing & Health

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The global prevalence of prediabetes is expected to reach 8.3% (587 million people) by 2045, with 70% of people with prediabetes developing diabetes during their lifetimes. We aimed to classify community‐dwelling adults with a high risk for prediabetes based on prediabetes‐related symptoms and to identify their characteristics, which might be factors associated with prediabetes. We analyzed homecare nursing records (n = 26,840) of 1628 patients aged over 20 years. Using a natural language processing algorithm, we classified each nursing episode as either low‐risk or high‐risk for prediabetes based on the detected number and category of prediabetes‐symptom words. To identify differences between the risk groups, we employed t‐tests, chi‐square tests, and data visualization. Risk factors for prediabetes were identified using multiple logistic regression models with generalized estimating equations. A total of 3270 episodes (12.18%) were classified as potentially high‐risk for prediabetes. There were significant differences in the personal, social, and clinical factors between groups. Results revealed that female sex, age, cancer coverage as part of homecare insurance coverage, and family caregivers were significantly associated with an increased risk of prediabetes. Although prediabetes is not a life‐threatening disease, uncontrolled blood glucose can cause unfavorable outcomes for other major diseases. Thus, medical professionals should consider the associated symptoms and risk factors of prediabetes. Moreover, the proposed algorithm may support the detection of individuals at a high risk for prediabetes. Implementing this approach could facilitate proactive monitoring and early intervention, leading to reduced healthcare expenses and better health outcomes for community‐dwelling adults.

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Prediabetes and gastrointestinal (GI) symptoms; a cross-sectional study

Cited by 6 publications

References 21 publications

Increased gastrointestinal symptom frequency in diabetes mellitus even with good glycemic control

Increased gastrointestinal symptom frequency in diabetes mellitus even with good glycemic control

Development and Validation of a Risk Nomogram Model for Predicting Constipation in Patients with Type 2 Diabetes Mellitus

Risk factors for prediabetes in community‐dwelling adults: A generalized estimating equation logistic regression approach with natural language processing insights

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