Prediabetes and Cardiovascular Disease

Brannick, Ben; Dagogo‐Jack, Samuel

doi:10.1016/j.ecl.2017.10.001

Cited by 186 publications

(90 citation statements)

References 138 publications

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“…Prediabetes is a state of intermediate hyperglycaemia that causes abnormal changes in intracellular metabolism of most body tissues including the liver [1]. Presently, the observed increase in the prevalence of prediabetes and type 2 diabetes mellitus (T2DM) in developed and developing countries is reported to be due to sedentary lifestyles coupled with high-caloric diets [1][2][3]. However, studies have shown that excessive intake of high-caloric diets induces skeletal muscle insulin resistance which results into the shunting of glucose from the skeletal muscle to the liver thereby leading to increased hepatic glycogen production and storage [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Akinnuga

Siboto

Khumalo

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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Background. Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. The effects of this compound on liver function, however, are unknown. This study was therefore designed to investigate the effects of BA on liver function in high fat-high carbohydrate (HFHC) diet-induced prediabetic rats. Methods. Thirty-six (36) male rats that weigh 150 g–180 g were divided into two groups, the non-prediabetic (n = 6) and the prediabetic groups (n = 30) that were fed normal diet (ND) and HFHC diet, respectively. The prediabetic rats were further subdivided into five groups (n = 6) and treated with either BA (80 mg/kg) or metformin (MET, 500 mg/kg) every third day for 12 weeks. After 12 weeks, blood samples and the liver were collected for biochemical analysis. Results. The induction of prediabetes resulted in increased release of liver enzymes (AST and ALT), increased liver glycogen and triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding protein (SREBP1c) and antioxidant enzymes. However, the administration of BA decreased liver enzyme concentrations, decreased hepatic oxidative stress, and improved antioxidant enzymes such as SOD and GPx. Conclusion. BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention.

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Section: Introductionmentioning

confidence: 99%

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Akinnuga

Siboto

Khumalo

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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“…2 3 Besides conferring increased risk for T2D, prediabetes is associated with vascular and neuropathic complications. [4][5][6] Several randomized clinical trials have demonstrated the efficacy of lifestyle interventions in delaying the development of T2D in people with prediabetes. [7][8][9][10][11] These landmark studies prespecified diabetes prevention, rather than reversal of prediabetes, as the primary outcome.…”

Section: Introductionmentioning

confidence: 99%

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study: design of lifestyle intervention

Dagogo‐Jack

Brewer

Owei

et al. 2020

BMJ Open Diab Res Care

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IntroductionIntensive lifestyle intervention (ILI) prevents progression from prediabetes to type 2 diabetes (T2D) but reversal of prediabetes is less well studied.Research design and methodsThe overall objectives of the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study (ClinicalTrials.gov ID: NCT02027571) are to determine the natural history and reversibility of prediabetes. The study tests specific hypotheses on the patterns of progression to prediabetes among normoglycemic African-American (AA) and European-American (EA) offspring of parents with T2D; emergence of microvascular and macrovascular complications during transition from normal to impaired glucose regulation; significance of the ‘metabolically healthy’ obese phenotype; and effect of duration of the prediabetic state on its reversibility with lifestyle intervention. Participants who developed incident prediabetes were offered ILI and evaluated quarterly for 5 years. The primary outcome was restoration of normal glucose regulation (fasting plasma glucose <100 mg/dL and two-hour plasma glucose (2hrPG)<140 mg/dL).ResultsOf the 223 subjects enrolled in the PROP-ABC Study, 158 participants with incident prediabetes started ILI. The mean age was 53.3±9.28 years; body mass index 30.6±6.70 kg/m2; 70% were female, 52.4% AA and 47.6% EA. The ILI program used goal setting, weight-based calorie restriction, physical activity (180 min/week), self-monitoring, and meal replacement. Monthly face-to-face (F2F) counseling sessions during the initial 6 months, and quarterly visits thereafter, were supplemented with electronic and postal contacts. Attendance at F2F sessions was highly correlated with weight loss (r=0.98, p<0.0001). Meal replacement induced ~5 kg weight loss within 3 months in participants with recrudescent weight pattern. Self-reported exercise minutes correlated with pedometer step counts (r=0.47, p<0.0001).ConclusionThe PROP-ABC Study has demonstrated the feasibility of executing an ILI program designed to test reversibility of incident prediabetes in a biracial cohort.

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“…The estimated prevalence of Chinese adults with prediabetes was 50.1%, and 493.4 million may have had prediabetes in 2010 [ 2 ]. Prediabetes is an important risk factor for diabetes [ 3 ] and many other diseases, such as cardiovascular diseases (CVD) [ 4 ], stroke [ 5 ], and nephropathy [ 6 ]. It was reported that the annual risk of progressing to diabetes in people with prediabetes was 5%–10% and up to 70% prediabetic patients would develop diabetes after years [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older

Zhao

Yang

Wang

et al. 2018

Journal of Diabetes Research

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Objective To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.48–1.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype with impaired glucose tolerance (IGT) (OR: 1.83; 95% CI: 1.57–2.13), but not with impaired fasting glucose (IFG) (OR: 0.87; 95% CI: 0.65–1.17). Only women with the HTGW phenotype are significantly associated with the combined IFG and IGT (OR: 1.83; 95% CI: 1.28–2.62). Conclusions The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT.

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Prediabetes and Cardiovascular Disease

Cited by 186 publications

References 138 publications

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study: design of lifestyle intervention

Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older

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