Prediabetes and Blood Pressure Effects on Heart Rate Variability, QT-Interval Duration, and Left Ventricular Hypertrophy in Overweight-Obese Adolescents

Lee, Shirleatha; Cowan, Patricia A.; Wetzel, Glenn T.; Velasquez-Mieyer, Pedro

doi:10.1016/j.pedn.2010.08.008

Cited by 9 publications

(11 citation statements)

References 74 publications

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“…Another study indicated that reduced HRV with higher psychological distress and increased salivary cortisol levels were observed in patients with temporomandibular disorders [31,32]. Another finding of the present study was the lack of significant differences between the two groups in the time and frequency domain parameters of the HRV, and this is in agreement with the results of Lee et al in a study of a large number of obese prediabetic adolescents that are similar to ours [33]. Additionally, Asghar et al demonstrated normal cardiac sympathetic innervation in prediabetic adults [34], a finding that reinforces our findings.…”

Section: Discussionsupporting

confidence: 93%

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Stefanaki

Michos

Latsios

et al. 2020

IJERPH

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Prediabetes in the form of impaired fasting glucose, impaired glucose tolerance, or both is considered as a preliminary stage for the onset of diabetes and diabetic complications. Hormonal fluctuations in adolescence are accompanied by body composition modifications, which are associated with insulin resistance and subclinical inflammation. Bioimpedance (BIA) accurately evaluates body composition, and heart rate variability (HRV) assesses cardiac autonomic function, which are frequently afflicted by insulin resistance. We aimed at evaluating the effect of glycemic status on mental stress, anxiety, and depression status in adolescents with impaired fasting glucose, body composition, and HRV parameters. This is a case-control study to evaluate the effect of the hyperglycemia on depression, anxiety, and stress levels (DASS21 questionnaire), body composition (BIA-ACC—BIOTEKNA©), and HRV (PPG Stress Flow—BIOTEKNA©), between euglycemic adolescents (euglycemic group) and adolescents with impaired fasting glucose (prediabetic group), aged 12–20 years. No differences were found between the prediabetic (n = 13) and the euglycemic (n = 16) groups in the outcome measures, possibly due to the number of participants. Interestingly, females, irrespective of their glycemic status, exhibited altered sympathovagal function as revealed by impaired HRV. In the euglycemic group, HRV parameters were significantly correlated and in line with the DASS21 scores, but in the prediabetic group, similarities to those of adults were observed. Impaired fasting glucose had no impact on mental health, body composition, or HRV parameters in adolescents. HRV parameters were impaired in females, irrespective of their glycemic status. This finding implies that females seem to be more prone to stress disorders, even from a young age. Future studies are needed to confirm these findings.

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Section: Discussionsupporting

confidence: 93%

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Stefanaki

Michos

Latsios

et al. 2020

IJERPH

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“…Such results were prospectively demonstrated by Lee et al [95], confirming the association between cardiac morphological alterations and prediabetic condition.…”

Section: Structural and Functional Changes In The Heart As A Results Osupporting

confidence: 64%

Endothelial Function in Pre-diabetes, Diabetes and Diabetic Cardiomyopathy: A Review

Ciccone

Scicchitano²,

Cameli³

et al. 2014

J Diabetes Metab

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Diabetes mellitus worsens cardiovascular risk profile of affected individuals. Its worldwide increasing prevalence and its negative influences on vascular walls morphology and function are able to induce the expression of several morbidities which worsen the clinical conditions of the patients getting them running towards a reduced survival curve.Although overt diabetes increases the mortality rate of individuals due to its pathogenesis, poor information are in literature about the role of pre-diabetes and family history of diabetes mellitus in the outcome of general population.This emphasizes the importance of early detection of vascular impairment in subjects at risk of developing diabetes.The identification of early stages of atherosclerotic diseases in diabetic persons is a fundamental step in the risk stratification protocols followed-up by physicians in order to have a complete overview about the clinical status of such individuals. Common carotid intima-media thickness, flow-mediated vasodilatation, pulse wave velocity are instrumental tools able to detect the early impairment in cardiovascular system and stratify cardiovascular risk of individuals.The aim of this review is to get a general perspective on the complex relationship between cardiovascular diseases onset, pre-diabetes and family history of diabetes. Furthermore, it points out the influence of diabetes on heart function till the expression of the so-called diabetic cardiomyopathy.

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“…Recent studies showed controversial results with respect to IFG [17] and the results were even insignificant after adding one more cardiovascular risk factor, obesity with it [18]. However, an early diagnosis of altered CAF may lead to an effective management of prediabetic state and reduce the CVD risk.…”

Section: Introductionmentioning

confidence: 99%

Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study

et al. 2012

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BackgroundThe worldwide burden of diabetes in 2030 is projected around 552 million. Diabetes leads to higher risk for cardiovascular diseases (CVD). Altered cardiac autonomic function (CAF) measured by heart rate variability (HRV) is observed in early stages of diabetes but the relationship between impaired fasting glucose (IFG) and HRV is still debatable. The aim of the study was to evaluate the association between CAF, oxidative stress, insulin resistance (IR), and inflammatory response in IFG subjects.Subjects and MethodsCross-sectional blinded study. Volunteers recruited from health awareness camps underwent CAF and biochemical tests. Based on fasting plasma glucose (FPG) participants (n = 123) were divided into two groups, normal fasting glucose (n = 76) and IFG (n = 47). The comparison of parameters between the groups was carried out using student t test and Mann-Whitney U test for parametric and non-parametric data respectively. The correlation between the parameters was analyzed by Spearman’s rank correlation using SPSS 13.0.ResultsThe resting cardiovagal modulation parameters, heart rate response to forced timed breathing, and orthostatic stress were reduced in IFG subjects. Fasting plasma lipid profile, coronary atherogenic lipid risk factors, IR, thiobarbituric acid reactive substance (TBARS), high sensitive C-reactive protein, and tumor necrosis factor alpha were increased and total antioxidant capacity (TAC) was decreased significantly in IFG group but no significant alteration was observed in high-density lipoprotein (HDL-c). Cardiovagal modulation parameters were negatively correlated with triglycerides, FPG, insulin, IR, TBARS, and inflammatory markers and positively with TAC.ConclusionThere is a continuous interplay between the altered CAF, hyperinsulinemia, IR, oxidative stress parameters, inflammatory response, and IFG in which one factor perpetuates another leading to the progression of disease.

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Prediabetes and Blood Pressure Effects on Heart Rate Variability, QT-Interval Duration, and Left Ventricular Hypertrophy in Overweight-Obese Adolescents

Cited by 9 publications

References 74 publications

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Sexual Dimorphism of Heart Rate Variability in Adolescence: A Case-Control Study on Depression, Anxiety, Stress Levels, Body Composition, and Heart Rate Variability in Adolescents with Impaired Fasting Glucose

Endothelial Function in Pre-diabetes, Diabetes and Diabetic Cardiomyopathy: A Review

Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study

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