2003
DOI: 10.1002/nrc.10083
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Predegenerated peripheral nerve graft with and without methylprednisolone administration after traumatic spinal cord injury in adult rats

Abstract: SUMMARYTraumatic spinal cord injury (TSCI) produces paralysis by destruction of axons and demyelination of surviving fibers. Using methylprednisolone (MP) as neuroprotector and a predegenerated peripheral nerve (PPN) graft as regenerative strategy, 83 rats with TSCI were divided into nongrafted, fresh peripheral nerve (FPN) and PPN grafted groups with and without MP administration. Myelination index (MI), number of axons, myelinated fibers, and axon collaterals were assessed 21 h, 7 days, 2, and 4 months after… Show more

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