Predator odor exposure in early adolescence influences the effects of the bacterial product, propionic acid, on anxiety, sensorimotor gating, and acoustic startle response in male rats in later adolescence and adulthood

Wah, Deanne Tak On; Ossenkopp, Klaus‐Peter; Bishnoi, Indra R.; Kavaliers, Martin

doi:10.1016/j.physbeh.2018.11.003

Cited by 10 publications

(4 citation statements)

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“…Increased anxiety-like behavior after PA administration has been reported in other studies as well. [64][65][66] Exploration activity and spatial learning and memory were not affected by HFD, CA, or PA. Other studies found cognitive deficits, increased motor activity, and impaired spatial memory in rats that were given PA. [67][68][69] However, these rats were given PA via intracerebroventricular injections with a relatively high dosage (4 μL of 0.26 M) of PA.…”

Section: F I G U R Ementioning

confidence: 90%

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice

et al. 2020

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Section: F I G U R Ementioning

confidence: 90%

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice

et al. 2020

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“…Many antipredator traits have evolved in response to predation risk, such as larger helmets in water fleas [24], tighter shoaling behavior in sticklebacks [25], and longer tails in common lizards [26]. Substantial evidence has demonstrated the effects of predatory stress during adolescence on adult phenotypes, including increased anxiety-like behavior [27][28][29][30][31][32][33], acoustic startle response [34], defensive response to a homotypic stressor [31,34], impaired extinction acquisition and retention of fear conditioning [35], decreased activity and pain sensitivity [36], depression-like behaviors [37], and dopamine D 2 receptors in the medial prefrontal cortex [29]. Exposure to predator stress in adolescence also decreases social interactions with conspecifics in adulthood [31,32], although social context may moderate the influence of such stressors [37,38].…”

Section: Introductionmentioning

confidence: 99%

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

Pang

et al. 2022

Neuroendocrinology

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Introduction: Stress during adolescence causes long-term behavioral changes in adulthood. We previously found that adolescent exposure to predatory risk augments adolescent social contact and adult parental behavior in Brandt’s voles (Lasiopodomys brandtii). Methods: Here we determined whether this experience alters sexual behavior, pair-bond formation, and recognition ability, as well as basal HPA axis activity, central oxytocin (OT), and arginine-vasopressin (AVP) expression in adulthood. Results: In the social interaction test, repeated cat odor (CO) exposure enhanced the frequency of lordosis by female voles toward an unfamiliar opposite-sex conspecific. CO voles preferred to engage with their partners after 48 h cohabitation whereas the control groups did not, which may reflect stable pair bonds in the CO treatment group. Furthermore, adolescent exposure to CO inhibited novel object and place recognition ability, while it influenced social recognition only among adult males. No effect of adolescent CO exposure was observed for basal HPA axis activity, showing a habituation effect. Finally, we found that CO exposure increased OT and decreased AVP expression in the hypothalamus, including the paraventricular nucleus and anterior hypothalamus. The levels of OT in the medial amygdala were lower, and AVP in the lateral septum was higher in CO voles compared with the control. Discussion/Conclusion: These findings demonstrate that adolescent exposure to predator risk promotes adult reproductive behavior of Brandt’s voles. Deficits in recognition ability may necessitate alterations in reproductive strategies to enhance inclusive fitness. OT and AVP systems may play a modulatory role in the alteration of social behaviors elicited by adolescent predatory risk.

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“…Хорошо известна реакция на запах хищника. У грызунов запах хищника вызывает аверсивную реакцию, изменение агрессивности и доминантности самцов, а также физиологические проявления стресса (Burwash et al 1998;Garcia et al 2015;Nolte et al 1994;Takahashi et al 2005;Wah et al 2019;Zhang et al 2003).…”

Section: Introductionunclassified

The influence of the smell of men and women on the behavior of laboratory rats

Анатольевич

Алексеевна²,

Павловна³

2021

Integrative Physiology

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The results of behavioral tests of laboratory animals are highly variable. Even within the same laboratory the results of the same test can differ significantly. We tested the effect of the experimenter's smell -male and female -on the behavior of male Wistar rats. The smell donors were clinically healthy non-smoking, low-alcohol-consuming volunteers aged 20-21: four men, and four women in the luteal phase of the menstrual cycle. They wore cotton socks and T-shirts at night, which, in the morning, were sealed in plastic bags. The animals were tested on the same day. In the first experiment (n = 20), smell samples were placed in the center of the elevated zero maze. First, we tested naive animals, after 20 days in the presence of a male smell, and after another 20 days in the presence of a female smell. The presence of human body smells during testing increased the rats' anxiety. A male smell had a greater effect than a female smell. In the second experiment (n = 29), the delayed effect of exposure to human smells was studied. The home cages were equipped with perforated plastic containers with fabric inside. They remained in the cages for one hour. During exposure to the smell, the animals were aroused, which was manifested in an intensive examination of containers and multiple agonistic contacts. Four hours later, increased anxiety was noted only after exposure to a female smell. The obtained data show that the results of behavioral tests on laboratory rats may depend, inter alia, on the sex of the experimenter.

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Predator odor exposure in early adolescence influences the effects of the bacterial product, propionic acid, on anxiety, sensorimotor gating, and acoustic startle response in male rats in later adolescence and adulthood

Cited by 10 publications

References 47 publications

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

The influence of the smell of men and women on the behavior of laboratory rats

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Predator odor exposure in early adolescence influences the effects of the bacterial product, propionic acid, on anxiety, sensorimotor gating, and acoustic startle response in male rats in later adolescence and adulthood

Cited by 10 publications

References 47 publications

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr −/− .Leiden mice

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr −/− .Leiden mice

Adolescence Predatory Risk Alters Social Behaviors and Cognitive Ability and Central Oxytocin and Vasopressin Expression in Adult Brandt’s Voles

The influence of the smell of men and women on the behavior of laboratory rats

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Product

Resources

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Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr ^−/− .Leiden mice