Precursors of thymic peptides as stress sensors

Лунин, С. М.; Хренов, М. О.; Глушкова, О. В.; Parfenyuk, Svetlana B.; Новоселова, Т. В.; Новоселова, Е. Г.

doi:10.1080/14712598.2020.1800636

Cited by 7 publications

(3 citation statements)

References 136 publications

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“…In particular, unlike thymulin, it has a predominantly negative role, suppressing the production of the hypothalamic releasing hormones thyrotropin releasing hormone (TRH), corticotropin-releasing hormone (CRH) and somatostatin. Moreover, data confirm that when applied intra-ventricularly, Tα1 decreases plasma ACTH, thyreotropin and prolactin but does not change GH levels [121,122]. In the end, other studies confirm the role of Tα1 in the hypothalamic-pituitary-adrenal axis and also indicate that the interactions between endocrine circuits and Tα1 are differential: while corticosteroids decrease the production of Tα1, estradiol augments the expression of [121,122].…”

Section: Thymosinsupporting

confidence: 56%

“…Moreover, data confirm that when applied intra-ventricularly, Tα1 decreases plasma ACTH, thyreotropin and prolactin but does not change GH levels [121,122]. In the end, other studies confirm the role of Tα1 in the hypothalamic-pituitary-adrenal axis and also indicate that the interactions between endocrine circuits and Tα1 are differential: while corticosteroids decrease the production of Tα1, estradiol augments the expression of [121,122].…”

Section: Thymosinsupporting

confidence: 56%

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Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

Rezzani

Franco

Hardeland

et al. 2020

IJMS

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For years the thymus gland (TG) and the pineal gland (PG) have been subject of increasingly in-depth studies, but only recently a link that can associate the activities of the two organs has been identified. Considering, on the one hand, the well-known immune activity of thymus and, on the other, the increasingly emerging immunological roles of circadian oscillators and the rhythmically secreted main pineal product, melatonin, many studies aimed to analyse the possible existence of an interaction between these two systems. Moreover, data confirmed that the immune system is functionally associated with the nervous and endocrine systems determining an integrated dynamic network. In addition, recent researches showed a similar, characteristic involution process both in TG and PG. Since the second half of the 20th century, evidence led to the definition of an effectively interacting thymus-pineal axis (TG-PG axis), but much has to be done. In this sense, the aim of this review is to summarize what is actually known about this topic, focusing on the impact of the TG-PG axis on human life and ageing. We would like to give more emphasis to the implications of this dynamical interaction in a possible therapeutic strategy for human health. Moreover, we focused on all the products of TG and PG in order to collect what is known about the role of peptides other than melatonin. The results available today are often unclear and not linear. These peptides have not been well studied and defined over the years. In this review we hope to awake the interest of the scientific community in them and in their future pharmacological applications.

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Section: Thymosinsupporting

confidence: 56%

Section: Thymosinsupporting

confidence: 56%

Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

Rezzani

Franco

Hardeland

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…TMPO is located on chromosome 12q22, is highly expressed in immune cells (BioGP, 2020) and plays an important role in T cell differentiation (Basch and Goldstein, 1974;Silva et al, 2009). It encodes thymopoietin or LAP2 known to be involved in nuclear architecture and chromatin organization by interacting with structural nuclear proteins such as lamins (Lunin et al, 2020). LAP2 binds to lamin B (Foisner and Gerace, 1993) and regulates the correct distribution of lamin B in the nucleus through its carboxy-terminal domain (Brady et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Interaction of HLA Class II rs9272219 and TMPO rs17028450 (Arg690Cys) Variants Affects Neuromyelitis Optica Spectrum Disorder Susceptibility in an Admixed Mexican Population

et al. 2021

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Neuromyelitis Optica Spectrum Disorder (NMOSD) is a demyelinating autoimmune disease of the central nervous system, more prevalent in individuals of non-European ancestry. Few studies have analyzed genetic risk factors in NMOSD, and HLA class II gene variation has been associated NMOSD risk in various populations including Mexicans. Thymopoietin (TMPO) has not been tested as a candidate gene for NMOSD or other autoimmune disease, however, experimental evidence suggests this gene may be involved in negative selection of autoreactive T cells and autoimmunity. We thus investigated whether the missense TMPO variant rs17028450 (Arg630Cys, frequent in Latin America) is associated with NMOSD, and whether this variant shows an interaction with HLA-class II rs9272219, previously associated with NMOSD risk. A total of 119 Mexican NMOSD patients, 1208 controls and 357 Native Mexican individuals were included. The HLA rs9272219 “T” risk allele frequency ranged from 21 to 68%, while the rs17028450 “T” minor allele frequency was as high as 18% in Native Mexican groups. Both rs9272219 and rs17028450 were significantly associated with NMOSD risk under additive models (OR = 2.48; p = 8 × 10–10 and OR = 1.59; p = 0.0075, respectively), and a significant interaction between both variants was identified with logistic regression models (p = 0.048). Individuals bearing both risk alleles had an estimated 3.9-fold increased risk of NMOSD. To our knowledge, this is the first study reporting an association of TMPO gene variation with an autoimmune disorder and the interaction of specific susceptibility gene variants, that may contribute to the genetic architecture of NMOSD in admixed Latin American populations.

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