Precursors of insulin resistance underlying periodontitis in adolescents aged 17–18 years

Ladeira, Lorena Lúcia Costa; Leite, Fábio Renato Manzolli; Nascimento, Gustavo G.; Saraiva, Maria da Conceição Pereira; Brondani, Mario; Moreira, Ana Regina Oliveira; Ribeiro, Cecília Cláudia Costa

doi:10.1111/odi.14283

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…It becomes more imperative when recent studies are reporting IR markers’ association with early signs of periodontal breakdown among adolescents. [ 93 ] However, it has often been ignored to be an imperative element of “interprofessional collaborative management approach” for T2D. [ 2 ] Therefore, oral and non-oral (medical) health professionals should line up efforts in the management of T2D-susceptible subjects with periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review

Bains

Mahendra

et al. 2022

J Int Soc Prevent Communit Dent

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A BSTRACT Aims and Objectives: The aim of the present paper is to provide a narrative review of the markers and pathways of periodontitis-associated insulin resistance (IR). Materials and Methods: Research papers published in peer-reviewed scientific journals from 2000 to 2021 were searched systematically in Online Cochrane Library, Google Scholar, and MedLine/PubMed database. The medical subject headings (MeSH) terms used for literature search were “diabetes AND periodontal disease,” “diabetes AND periodontitis,” “inflammation AND insulin resistance,” “Insulin resistance AND periodontal disease,” and “insulin resistance AND periodontitis.” Manual search for applicable work in review article peer-reviewed print journals, and latest editions of standard textbooks of pharmacology and pathology were searched for updated additional information. Relevant papers in English language on the topic and abstracts of pertinent articles after excluding the duplicates, animal studies, and in-vitro studies were also scrutinized thoroughly and finally included as required in this narrative review. Results: Literature search in MedLine/PubMed with MeSH words mentioned above revealed 4,621, 4,993, 19,349, 414, and 434 papers, respectively. Seven out of 13 systematic reviews and a total of 18 randomized clinical trials to evaluate periodontitis-induced IR were short-listed to update current evidences. The current literature in the past two decades has evaluated the effect of periodontal therapy on various type-2 diabetes (T2D) biomarkers following periodontal therapy. These indicators of periodontal disease activity and surrogate biomarkers of T2D in periodontitis may be an important diagnostic tool for the early prediction of complications due to IR. This increased systemic burden of proinflammatory cytokines by periodontitis can be reduced by periodontal therapy, thus improving the patient’s overall systemic condition. Conclusion: The inflammatory response in periodontitis is characterized by dysregulated secretion of host-derived mediators of inflammation and tissue breakdown that may lead to IR. It can be comprehended that periodontal disease is a recognized amendable risk factor for T2D.

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Section: Discussionmentioning

confidence: 99%

Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review

Bains

Mahendra

et al. 2022

J Int Soc Prevent Communit Dent

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Obesity, Insulin Resistance, Caries, and Periodontitis: Syndemic Framework

Ladeira,

Nascimento,

Leite

et al. 2023

Nutrients

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(1) Background: To investigate the grouping of obesity and insulin resistance with caries and periodontitis from a syndemic perspective through pathways of socioeconomic inequalities, smoking, alcohol, and high sugar consumption in adolescence. (2) Methods: The population-based RPS Cohort study, São Luís, Brazil, in ages 18–19 years (n = 2515) was used. The outcomes were the grouping of pbesity and Insulin Resistance Phenotype (latent variable formed by Triglycerides/HDL ratio, TyG index, and VLDL) and the Chronic Oral Disease Burden (latent variable comprising caries, bleeding on probing, probing depth ≥ 4 mm, clinical attachment level ≥ 3 mm, and visible plaque index ≥ 15%). Socioeconomic Inequalities influencing the Behavioral Risk Factors (latent variable formed by added sugar, smoking, and alcohol) were analyzed using structural equation modeling. (3) Results: Socioeconomic Inequalities were associated with the Chronic Oral Disease Burden [Standardized Coefficient (SC) = 0.222, p < 0.001]. Behavioral Risk Factors were associated with increased Chronic Oral Disease Burden (SC = 0.103; p = 0.013). Obesity was associated with the Insulin Resistance Phenotype (SC = 0.072; p < 0.001) and the Chronic Oral Disease Burden (SC = 0.066; p = 0.005). The Insulin Resistance Phenotype and the Chronic Oral Disease Burden were associated (SC = 0.053; p = 0.032). (4) Conclusion: The grouping of obesity and early events of diabetes with caries and periodontitis call for a syndemic approach in adolescence.

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Precursors of insulin resistance underlying periodontitis in adolescents aged 17–18 years

Cited by 2 publications

References 49 publications

Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review

Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review

Obesity, Insulin Resistance, Caries, and Periodontitis: Syndemic Framework

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