Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor

Abstract

A primary extramedullary myeloid cell tumor (pEMT) of an inguinal lymph node was completely excised without subsequent anti-tumor therapy in a 6-year-old child. Clinical observation and monitoring of blood and bone marrow (BM) did not reveal any pathologic results before 32 months, when a precursor B lymphoblastic leukemia was diagnosed. Identical T-cell receptor gamma rearrangement in nodal pEMT and in precursor B lymphoblastic leukemia in BM indicates a clonal relationship of these two tumors.

Clinicopathological Characteristics of Extramedullary Acute Megakaryoblastic Leukemia (AMKL): Report of a Case with Initial Mastoid Presentation and Review of Literature to Compare Extramedullary AMKL and Non-AMKL Cases

“…In addition to the AMKL patient reported in this article, 103 cases of extramedullary AML at the time of initial diagnosis in pediatric patients were found in the English-language literature (102 cases) from 1971–2011 and in the archives of Children's Hospital Colorado (1 case) from 1990–2011. Of these, 9 cases were AMKL [5–8,10] and 94 cases were non-AMKL [11–77]. Nineteen of the 94 non-AMKL pat...…”