Preconditioning With Oxygen Attenuates Rat Renal Ischemia–Reperfusion Injury

Rasoulian, Bahram; Mohammadhosseniakbari, Hassan; Kadkhodaee, Mehri; Mofid, Mahmood; Baqeri, Gholamreza; Bigdeli, Mohammad Reza; Ghasemi, Asghar; Mohebbi, Hassan Ali; Asgari, Asghar; Khoshbaten, Ali

doi:10.1016/j.jss.2007.04.034

Cited by 17 publications

(21 citation statements)

References 39 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,12,13 The present study demonstrates that this beneficial effect of oxygen pretreatment also is present in human renal tubular cells. Previously proposed mechanisms which could also explain somewhat the present study findings, is that sub-lethal excess amount of free radicals produced during oxygen pretreatment 29 may act as a mediator for induction of cellular protective agents like antioxidant enzymes, 13 heat shock proteins (Wahhabaghai et al, unpublished data) and probably other endogenous defense mechanisms.…”

Section: Discussionsupporting

confidence: 67%

“…3,11 Previous animal studies have shown that short-term pretreatment with nearly pure oxygenwithout closing to the oxygen toxicity threshold-could lead to some degrees of protection against Cisplatin induced nephrotoxicity and both renal and cardiac ischemic damages. 6,[12][13][14][15] This protective effect may be due to stimulating the endogenous defense mechanisms such as antioxidant systems against free radicals by mild hyperoxia-induced oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment

Kaeidi¹,

Rasoulian²,

Hajializadeh³

et al. 2013

Renal Failure

Self Cite

View full text Add to dashboard Cite

Cisplatin is an effective and widely used chemotherapy agent and its side effects, particularly nephrotoxicity, limit its usage and related platinum-based drugs. Cisplatin nephrotoxicity is mainly due to extremely increase in reactive oxygen species (ROS) generation leading to kidney tubular cell death. Preconditioning with oxidative stress has been demonstrated to stimulate the cellular adaptation to subsequent severe oxidative stress. Short term oxygen pre-exposure as a mild oxidative stress may enhance some endogenous defense mechanisms, so its effect on Cisplatin induced cell death was investigated in present research. We studied the effects of hyperoxic environment pre-exposure on Cisplatin toxicity in an in-vitro model of cultured human embryonic tubular epithelial cells (AD293). Viability of AD293 cells, as evaluated by MTT-assay, was affected by Cisplatin in a time (1-4 h) dependent model. Biochemical markers of cell apoptosis were evaluated using immunoblotting. Pretreatment with nearly pure oxygen (!90%) for 2 h significantly reduced the level of cell damage. Activated caspase 3 and Bax/Bcl-2 ratio were significantly increased in Cisplatin-treated cells. Oxygen pretreatment inhibited caspase 3 activation and decreased Bax/Bcl-2 ratio. Oxygen pre-treatment itself not showed any cytotoxicity in exposure times up to 3 h. Our data indicate that hyperoxic preconditioning reduces Cisplatin toxicity in cultured human tubular epithelial cells. The exact mechanism of protection is unclear, though enhancement of some endogenous defense mechanisms and subsequently scavenging of free oxygen radicals may play an important role.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment

Kaeidi¹,

Rasoulian²,

Hajializadeh³

et al. 2013

Renal Failure

Self Cite

View full text Add to dashboard Cite

show abstract

“…[7,8] We have shown recently that intermittent pretreatment of rats with nearly pure oxygen for durations far beyond the oxygen toxicity threshold could lead to some degree of renal protection against ischemia-reperfusion injury. [9] Cisplatin causes significant oxidant loading to the kidney through both free radical formation and impaired antioxidant defense systems. [10] The hypothesis underlying the present study is that mild oxidative stress induced by oxygen pre-exposure [11] may enhance some endogenous defense mechanisms such as renal antioxidant systems and reduce subsequent cisplatin-induced kidney damage resulting from reactive oxygen species.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that pre-exposure to normobaric hyperoxia could be protective against subsequent brain, [29] heart, [30] spinal cord, [31] and renal IR injury. [9] Atasoyu et al concluded that the synchronous application of HBO therapy (60 min every day for seven days at 2.5 ATA) with cisplatin prevents kidney damage by decreasing necrosis scores. [32] In our study, only two sessions of normobaric oxygen administration were used 24 h before cisplatin injection.…”

mentioning

confidence: 99%

Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

et al. 2010

Self Cite

View full text Add to dashboard Cite

Cisplatin (CP) nephrotoxicity is mainly due to reactive oxygen species. Oxygen pre-exposure as a mild oxidative stress may enhance some endogenous defense mechanisms, so its effect on cisplatininduced acute renal failure was investigated in present study.Twenty-four rats were divided into four groups. The O 2 + CP and Air + CP groups were were subjected to i.p. injection of 5 mg/kg cisplatin, and in the Air + Saline and O 2 + Saline groups, saline was injected instead of cisplatin. O 2 + CP and O 2 + Saline groups were pretreated with oxygen (3h/d for two days), and the other two groups were pretreated with room air. Cisplatin was administered 24 h after last pretreatment session. Three days after cisplatin injection, plasma samples were obtained, and parts of kidney tissue were frozen for biochemical analysis or fixed in formalin for histological assessments. Preconditioning with oxygen prior to cisplatin administration led to reduced tubular necrosis and luminal cast formation and improvement of renal function, as was evidenced by significant reduction in plasma creatinine and urea levels. Oxygen pretreatment also significantly reversed cisplatin-induced reduction in renal catalase activity and glutathione level. It could be concluded that oxygen pretreatment could have a delayed protective effect against cisplatin nephrotoxicity, and that increased renal catalase activity may be involved in this protective effect of hyperoxia.

show abstract

“…Importantly, it was revealed that the protective effects of pure oxygen exposure on rat heart tissue can be seen with 80% oxygen as well 13 and this may be true for other tissues such as kidney. 14 Some studies suggest that intermittent and prolonged normobaric hyperoxia induces brain ischemic tolerance. 15,16 Bigdeli et al showed the intermittent and prolonged normobaric hyperoxia resulted in increase antioxidant enzymes activities.…”

mentioning

confidence: 99%

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Saadat¹,

Maghani²,

Rahimi³

et al. 2013

Renal Failure

View full text Add to dashboard Cite

Background: Cisplatin is a potent anticancer drug, but its nephrotoxicity limits the clinical use of it. To reduce the Cisplatin-induced nephrotoxicity, various interventions have been implicated. The aim of this study was to examine whether preconditioning with normobaric hyperoxia would prevent Cisplatin-induced nephrotoxicity in patient with solid tumor. Methods: In a prospective study, 80 adult patients with solid tumor who were treated with Cisplatin between February 2011 and December 2011 were included. Forty-three patients were exposed to pure oxygen via non-rebreathing reservoir mask which increased the provided oxygen rate to 60% oxygen for 2 hours at 48, 24, and 6 hours before intravenous administration of Cisplatin and 37 patients received only Cisplatin as a control group. Estimated glomerular filtration rate (eGFR) calculated in all patients on day 1 before and on days 1, 3, 6, 30 after Cisplatin exposures. Results: Patients treated with Cisplatin and 60% oxygen showed a mild improvement in eGFR and mild reduction of serum creatinine after 30 days with statistically mild significant differences (p ¼ 0.048). Conclusion: This study showed that normobaric and intermittent precondition of 60% oxygen prior to Cisplatin treatment had an acute transient adverse effect on renal function; however, the improvement of renal function will be seen after 30 days. Thus, it may help to prevent Cisplatin nephrotoxicity.

show abstract

Preconditioning With Oxygen Attenuates Rat Renal Ischemia–Reperfusion Injury

Cited by 17 publications

References 39 publications

Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment

Cisplatin toxicity reduced in human cultured renal tubular cells by oxygen pretreatment

Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Contact Info

Product

Resources

About