Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner

Segev-Amzaleg, Niva; Trudler, Dorit; Frenkel, Dan

doi:10.1016/j.bbi.2012.12.016

Cited by 32 publications

(14 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, we observed an increase in the anti-inflammatory cytokine IL-10 before asphyxia. IL-10 can reduce hypoxia-induced hyperexcitability in hippocampal slice neurons [38], and is an essential mediator of astroglial pre-conditioning to mild oxidative stress in culture [39]. Sevoflurane-induced postconditioning of global cerebral ischemia in adult rats is associated with suppression of pro-inflammatory cytokines and increased IL-10 [40].…”

Section: Discussionmentioning

confidence: 99%

Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

Heuij

Mathai

Davidson

et al. 2014

J Neuroinflammation

View full text Add to dashboard Cite

BackgroundPerinatal asphyxia and exposure to intrauterine infection are associated with impaired neurodevelopment in preterm infants. Acute exposure to non-injurious infection and/or inflammation can either protect or sensitize the brain to subsequent hypoxia-ischemia. However, the effects of subacute infection and/or inflammation are unclear. In this study we tested the hypothesis that acute-on-chronic exposure to lipopolysaccharide (LPS) would exacerbate white matter injury after subsequent asphyxia in preterm fetal sheep.MethodsFetal sheep at 0.7 gestational age received a continuous LPS infusion at 100 ng/kg for 24 hours, then 250 ng/kg/24 hours for 96 hours, plus 1 μg boluses of LPS at 48, 72, and 96 hours or the same volume of saline. Four hours after the last bolus, complete umbilical cord occlusion or sham occlusion was induced for 15 minutes. Sheep were sacrificed 10 days after the start of infusions.ResultsLPS exposure was associated with induction of microglia and astrocytes and loss of total and immature and mature oligodendrocytes (n = 9) compared to sham controls (n = 9). Umbilical cord occlusion with saline infusions was associated with induction of microglia, astrogliosis, and loss of immature and mature oligodendrocytes (n = 9). LPS exposure before asphyxia (n = 8) was associated with significantly reduced microglial activation and astrogliosis and improved numbers of immature and mature oligodendrocytes compared to either LPS exposure or asphyxia alone.ConclusionsContrary to our initial hypothesis, the combination of acute-on-chronic LPS with subsequent asphyxia reduced neuroinflammation and white matter injury compared with either intervention alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

Heuij

Mathai

Davidson

et al. 2014

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

“…The transcription factor Nrf2 is expressed widely throughout the body and upregulates the expression of numerous antioxidant genes in response to oxidative stress (88, 89). In astroglia preconditioned to oxidative stress, neuroprotection from oxidative stress–glucose deprivation was reported to be via an Nrf2/IL-10-dependent mechanism (90). Lipocalin-2 is significantly increased in neurons following stroke and is proposed to signal stress from injured neurons to supporting glia (91).…”

Section: Ischemic Strokementioning

confidence: 99%

Role of Interleukin-10 in Acute Brain Injuries

et al. 2017

View full text Add to dashboard Cite

Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 in modulating outcomes following acute brain injury, including traumatic brain injury (TBI) and the various stroke subtypes. The vascular endothelium is closely tied to the pathophysiology of these neurological disorders and research has demonstrated clear vascular endothelial protective properties for IL-10. In vitro and in vivo models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. Comparatively, conclusive studies investigating the contribution of IL-10 in subarachnoid hemorrhage are lacking. Weak indirect evidence supporting the protective role of IL-10 in preclinical models of intracerebral hemorrhage exists; however, in the limited number of clinical studies, higher IL-10 levels seen post-ictus have been associated with worse outcomes. Similarly, preclinical TBI models have suggested a neuroprotective role for IL-10; although, controversy exists among the several clinical studies. In summary, while IL-10 is consistently elevated following acute brain injury, the effect of IL-10 appears to be pathology dependent, and preclinical and clinical studies often paradoxically yield opposite results. The pronounced and potent effects of IL-10 in the resolution of inflammation and inconsistency in the literature regarding the contribution of IL-10 in the setting of acute brain injury warrant further rigorously controlled and targeted investigation.

show abstract

“…Such stimulatory responses reflect either a direct stimulation or an overcompensatory effect, and occur independently of biological model, cell type, inducing agent, and mechanism (Calabrese, 2011, ). Hormetic effects are currently being ever more considered for biomedically therapeutic applications (Calabrese, ) in that these responses appear to be involved in a number of developmental, maturational, and aging processes (Calabrese et al, ; Segev‐Amzaleg, Trudler, & Frenkel, ), and may subserve a spectrum of activities in neural systems, including protection against and/or recovery from certain neurodegenerative diseases, and/or injury (Calabrese, ). The iterative recognition of hormesis has occurred in large part because traditional dose–response constructs, such as the threshold model, have not been able to satisfactorily and/or fully account for nonrandom biological activity below well‐established thresholds of response.…”

Section: Hormesis: Background and Perspectivesmentioning

confidence: 99%

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Calabrese

Santoro

Salinaro

et al. 2018

J of Neuroscience Research

View full text Add to dashboard Cite

Age-related changes in the brain reflect a dynamic interaction of genetic, epigenetic, phenotypic, and environmental factors that can be temporally restricted or more longitudinally present throughout the lifespan. Fundamental to these mechanisms is the capacity for physiological adaptation through modulation of diverse molecular and biochemical signaling occurring from the intracellular to the network-systemic level throughout the brain. A number of agents that affect the onset and progression of Parkinson's disease (PD)-like effects in experimental models exhibit temporal features, and mechanisms of hormetic dose responses. These findings have particular significance since the hormetic dose response describes the amplitude and range of potential therapeutic effects, thereby affecting the design and conduct of studies of interventions against PD (and other neurodegenerative diseases), and may also be important to a broader consideration of hormetic processes in resilient adaptive responses that might afford protection against the onset and/or progression of PD and related disorders.

show abstract

Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner

Cited by 32 publications

References 54 publications

Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

Role of Interleukin-10 in Acute Brain Injuries

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Contact Info

Product

Resources

About