Preconditioning the human myocardium

Yellon, Derek M.; Alkhulaifi, Abdulaziz; Pugsley, W

doi:10.1016/0140-6736(93)91819-8

Cited by 626 publications

(298 citation statements)

References 6 publications

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“…Studies of human myocardium obtained at the time of cardiac surgery have demonstrated better preservation of ATP during 10-minute periods of aortic cross-clamp fibrillation when hearts were exposed to prior 3-minute episodes of ischemia. 235 In addition, in the same model, it has recently been shown that troponin release is significantly attenuated in patients who had been preconditioned previously. 236 Studies using human cardiac muscle (atrial trabeculae) confirm findings in the animal laboratory with respect to initiation of preconditioning with hypoxia and the adenosine A 1 agonist rPIA.…”

Section: Clinical Evidence For Preconditioningmentioning

confidence: 99%

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

et al. 1998

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Section: Clinical Evidence For Preconditioningmentioning

confidence: 99%

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

et al. 1998

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“…The use of preconditioning in the clinic has hitherto been primarily conduced in the heart during cardiac bypass graft (CABG) surgery and angioplasty. For example Yellon et al, [172] induced IPC by aortic cross-clamping for 2 min followed by 3 min of reperfusion two times prior to CABG surgery. Patients which received IPC treatment in this study maintained ATP levels in ventricular biopsies and displayed reduced serum troponin T levels.…”

Section: Discussionmentioning

confidence: 99%

Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning

Thompson¹,

Narayanan²,

Pérez-Pinzón³

2012

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There is extensive evidence that the restoration of blood flow following cerebral ischemia contributes greatly to the pathophysiology of ischemia mediated brain injury. The initiating stimulus of reperfusion injury is believed to be the excessive production of reactive oxygen (ROS) and nitrogen (RNS) species by the mitochondria. ROS and RNS generation leads to mitochondrial protein, lipid and DNA oxidation which impedes normal mitochondrial physiology and initiates cellular death pathways. However not all ROS and RNS production is detrimental. It has been demonstrated that low levels of ROS production are protective and may serve as a trigger for activation of ischemic preconditioning. Ischemic preconditioning is a neuroprotective mechanism which is activated upon a brief sublethal ischemic exposure and is sufficient to provide protection against a subsequent lethal ischemic insult. Numerous proteins and signaling pathways have been implicated in the ischemic preconditioning neuroprotective response. In this review we examine the origin and mechanisms of ROS and RNS production following ischemic/reperfusion and the role of free radicals in modulating proteins associated with ischemic preconditioning neuroprotection.

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“…YELLON et al [19] in a clinical work on preconditioning in patients submitted to CABG, reported the preservation of the ATP in subsequent periods of ischemia, indicating ischemic tolerance of the human myocardium.…”

Section: Commentsmentioning

confidence: 99%

Prognostic implications of myocardial creatine kinase and cardiac troponin in coronary artery bypass surgery

Taniguchi¹,

Pěgo‐Fernandes²,

Jatene³

et al. 2003

Rev Bras Cir Cardiovasc

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Objectives: To evaluate the prognostic implications of myocardial creatine kinase and troponin I (cTn I) in blood samples from the coronary sinus of patients submitted to coronary artery bypass surgery both with and without ischemic preconditioning.Methods: From October 1998 to May 1999, 35 patients with coronary artery disease who were submitted to coronary artery bypass surgery were studied. Samples containing creatine kinase and cTn I were obtained from the great cardiac vein during surgery at the onset of cardiopulmonary bypass, at the end of the first anastomosis, and at the end of cardiopulmonary bypass. In May 2002, 29 patients were evaluated in regards to the angina functional class, congestive heart failure, number of hospitalizations, myocardial infarction and death. There were 15 patients in the Preconditioned group and 14 in the Control group. Each group was subdivided into patients with and without cardiovascular symptoms. Results:The Control and Preconditioned groups were not significantly different in relation to frequency of cardiovascular symptoms. There were progressive increases of the creatine kinase and cTn I levels at different Interval s of the study. The cTn I in the Preconditioned group was 1.21 ± 0.64 ng/mL and 3.19 ± 3.21 ng/mL in the Control group (p<0.05). The Control group with symptoms had the highest level for cTn I of 5.07 ± 3.69 ng/mL, significantly higher than all other groups (p<0.05).Conclusions: The Preconditioned group had the lowest level of cTn I. The cTn I may be a marker for late evolution in patients submitted to coronary artery bypass surgery.Descriptors: Myocardial revascularization. Myocardial ischemic preconditioning. Myocardial ischemia, physiology. Troponin. Cardiovasc 2003; 18(3): 210-216 Rev Bras Cir

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Preconditioning the human myocardium

Cited by 626 publications

References 6 publications

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning

Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning

Prognostic implications of myocardial creatine kinase and cardiac troponin in coronary artery bypass surgery

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