Preconditioning as a Potential Strategy for the Prevention of Parkinson's Disease

Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway

“…The pathological processes underlying PD involves oxidative stress, impaired antioxidant response, mitochondrial dysfunction, and accumulation of a-synuclein aggregates [2]. MicroRNAs (miRNAs) are small non-coding RNAs that have been recently identified as post-transcriptional regulators of gene expression with relevant roles in physiological and pathological aspects of the central nervous system [3,4].…”

Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

“…The pathological processes underlying PD involves oxidative stress, impaired antioxidant response, mitochondrial dysfunction, and accumulation of ␣-synuclein aggregates. These changes are known to exacerbate the cellular damage in dopaminergic neurons [8]. Currently, l-dopa, the precursor of the neurotransmitter dopamine remains the most effective treatment for PD symptoms.…”